Effects of dietary deprivation, obesity and exercise on UCP3 mRNA levels.

被引：13

作者：

Giacobino, JP ^{[1
]}

机构：

[1] Ctr Med Univ Geneva, Dept Biochim Med, CH-1211 Geneva 4, Switzerland

来源：

INTERNATIONAL JOURNAL OF OBESITY | 1999年 / 23卷 / Suppl 6期

关键词：

brown adipose tissue; skeletal muscle; cold; fasting; fatty acids; leptin;

D O I：

10.1038/sj.ijo.0800949

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Uncoupling protein-3 (UeP3) is selectively expressed in skeletal muscle of rodents and humans, and in brown adipose tissue (BAT) of rodents. C2C12 myoblast transfection with UCP3 induced a decrease in mitochondrial membrane potential suggesting that UCP3 behaves as an uncoupler of oxidative phosphorylations. Cold-exposure, food restriction and fasting affect UCP3 mRNA expression differently in BAT, compared to muscle. The effects induced by cold-exposure and fasting in BAT, and by fasting in muscle, might be explained by changes in intracellular free fatty acids (FFA). A single bout of exercise or endurance training, respectively, increases or decreases muscle UCP3 expression. The effects of PPAR gamma agonists and leptin on BAT and muscle UCP3 mRNA expression are also discussed. Hypotheses to explain the effects of these modulations are presented.

引用

页码：S60 / S63

页数：4

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