Picornavirus receptor down-regulation by plasminogen activator inhibitor type 2

被引:22
作者
Shafren, DR
Gardner, J
Mann, VH
Antalis, TM
Suhrbier, A
机构
[1] Univ Newcastle, Fac Med & Hlth Sci, Discipline Immunol & Microbiol, Picornaviral Res Unit, Newcastle, NSW 2300, Australia
[2] Queensland Inst Med Res, Cellular Oncol Lab, Brisbane, Qld 4029, Australia
[3] Queensland Inst Med Res, Australian Ctr Int & Trop Hlth & Nutr, Brisbane, Qld 4029, Australia
[4] Univ Queensland, Brisbane, Qld 4029, Australia
关键词
D O I
10.1128/JVI.73.9.7193-7198.1999
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Therapeutic interference with virus-cell surface receptor interactions represents a viable antiviral strategy. Here we demonstrate that cytoplasmic expression of the serine protease inhibitor (serpin), plasminogen activator inhibitor type 2 (PAI-2), affords a high level of protection from lytic infection by multiple human picornaviruses. The antiviral action of PAI 2 was mediated primarily through transcriptional down-regulation of the following virus receptors: intercellular adhesion molecule 1 (ICAM-1, a cellular receptor for the major group of rhinoviruses), decay-accelerating factor (a cellular receptor for echoviruses and coxsackieviruses), and to a lesser extent the coxsackie-adenovirus receptor protein (a cellular receptor for group B coxsackieviruses and group C adenoviruses). Expression of related cell surface receptors, including membrane cofactor protein and the poliovirus receptor, remained unaffected. These findings suggest that PAI-2 and/or related serpins may form the basis of novel antiviral strategies against picornavirus infections and also therapeutic interventions against ICAM-1-mediated respiratory inflammation.
引用
收藏
页码:7193 / 7198
页数:6
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