Repeated experience of social defeats increases serotonin transporter and monoamine oxidase A mRNA levels in raphe nuclei of male mice

被引：42

作者：

Filipenko, ML

Beilina, AG

Alekseyenko, OV

Dolgov, VV

Kudryavtseva, NN

机构：

[1] Russian Acad Sci, Inst Bioorgan Chem, Siberian Dept, Grp Eukariot Genes Express Res, Novosibirsk 630090, Russia

[2] Russian Acad Sci, Inst Cytol & Genet, Siberian Dept, Sector Social Behav Neurogenet, Novosibirsk 630090, Russia

来源：

NEUROSCIENCE LETTERS | 2002年 / 321卷 / 1-2期

关键词：

serotonin transporter; monoamine oxidase A; multiplex reverse transcription-polymerase chain reaction; mice; agonistic behavior; sensory contact model;

D O I：

10.1016/S0304-3940(01)02495-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Serotonin transporter (SERT) and monoamine oxidase A (MAOA) mRNA levels in the raphe nuclei area of the midbrain were measured by the multiplex reverse transcription-polymerase chain reaction method in male mice with repeated experience of social victories (winners) and defeats (losers) in ten daily agonistic confrontations. Experiments revealed enhanced SERT and MAOA mRNA levels in the losers compared with the winners and controls. It has been supposed that SERT and MAOA genes are involved in enhancement of serotonin inactivation in response to the increase of serotonergic activity shown earlier in the losers. A positive correlation between MAOA and SERT mRNA levels in the raphe nuclei area of the midbrain was shown. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：25 / 28

页数：4

共 21 条

[1] CHRONIC ADMINISTRATION OF CLOMIPRAMINE PREVENTS THE INCREASE IN SEROTONIN AND NORADRENALINE INDUCED BY CHRONIC STRESS [J].

ADELL, A ;

GARCIAMARQUEZ, C ;

ARMARIO, A ;

GELPI, E .

PSYCHOPHARMACOLOGY, 1989, 99 (01) :22-26

[2] Effect of repeated experience of victory and defeat in daily agonistic confrontations on brain tryptophan hydroxylase activity [J].

Amstislavskaya, TG ;

Kudryavtseva, NN .

FEBS LETTERS, 1997, 406 (1-2) :106-108

[3] Serotonin, stress and corticoids [J].

Chaouloff, F .

JOURNAL OF PSYCHOPHARMACOLOGY, 2000, 14 (02) :139-151

[4]

CHATTOPADHYAY N, 1993, BIOTECHNIQUES, V15, P24

[5] IMPULSIVE AGGRESSION AND CENTRAL SEROTONERGIC SYSTEM FUNCTION IN HUMANS - AN EXAMPLE OF A DIMENSIONAL BRAIN-BEHAVIOR RELATIONSHIP [J].

COCCARO, EF .

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 1992, 7 (01) :3-12

[6] Selective reduction of monoamine oxidase A and B in the frontal cortex of subordinate rats [J].

Dhingra, NK ;

Raju, TR ;

Meti, BL .

BRAIN RESEARCH, 1997, 758 (1-2) :237-240

[7]

Filipenko ML, 2002, STRESS: NEURAL, ENDOCRINE AND MOLECULAR STUDIES, P157

[8]

FILIPENKO ML, 2001, IN PRESS MOL BRAIN R

[9]

KUDRYAVTSEVA NN, 1991, ZH VYSSH NERV DEYAT+, V41, P459

[10]

KUDRYAVTSEVA NN, 1991, AGGRESSIVE BEHAV, V17, P285, DOI 10.1002/1098-2337(1991)17:5<285::AID-AB2480170505>3.0.CO

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