Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family

被引：418

作者：

Wolfman, NM ^{[1
]}

Hattersley, G ^{[1
]}

Cox, K ^{[1
]}

Celeste, AJ ^{[1
]}

Nelson, R ^{[1
]}

Yamaji, N ^{[1
]}

Dube, JL ^{[1
]}

DiBlasioSmith, E ^{[1
]}

Nove, J ^{[1
]}

Song, JJ ^{[1
]}

Wozney, JM ^{[1
]}

Rosen, V ^{[1
]}

机构：

[1] GENET INST INC,CAMBRIDGE,MA 02140

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1997年 / 100卷 / 02期

关键词：

tendon; ligament; bone morphogenic proteins; tissue repair; orthopedics;

D O I：

10.1172/JCI119537

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Little is known about the regulatory signals involved in tendon and ligament formation, and this lack of understanding has hindered attempts to develop biologically based therapies for tendon and ligament repair, Here we report that growth and differentiation factors (GDFs) 5, 6, and 7, members of the TGF-P gene superfamily that are most related to the bone morphogenetic proteins, induce neotendon/ligament formation when implanted at ectopic sites in vivo. Analysis of tissue induced by GDF-5, 6, or 7, containing implants by currently available morphological and molecular criteria used to characterize tendon and ligament, adds further evidence to the idea that these GDFs act as signaling molecules during embryonic tendon/ligament formation, In addition, comparative in situ localizations of the GDF-5, 6, and 7 mRNAs suggest that these molecules are important regulatory components of synovial joint morphogenesis.

引用

页码：321 / 330

页数：10

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