CD4+ T cells mediate cytotoxicity in neurodegenerative diseases

被引：78

作者：

Appel, Stanley H. ^{[1
]}

机构：

[1] Methodist Neurol Inst, Dept Neurol, Houston, TX 77030 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2009年 / 119卷 / 01期

关键词：

DOPAMINERGIC NEURODEGENERATION; MICROGLIAL ACTIVATION; PARKINSONS-DISEASE; MOUSE MODEL; DEGENERATION; NEURONS; SYSTEM; ALS;

D O I：

10.1172/JCI38096

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Neuroinflammation, characterized by activated microglia and infiltrating T cells, is a prominent pathological feature in neurodegenerative diseases. However, whether this inflammation contributes to neuronal injury or is a late consequence of neuronal injury is unclear. In this issue of the JCI, Brochard et al. report that CD4(+) T cells are cytotoxic in a mouse model of Parkinson disease (PD) (see the related article beginning on page 182). Specifically, invading T lymphocytes contributed to neuronal cell death via the Fas/FasL pathway. The results implicate the adaptive immune system in the pathogenesis of Parkinson neurodegeneration and provide a meaningful rationale for immune-based therapies for PD.

引用

页码：13 / 15

页数：3

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