Relation between muscle fiber conduction velocity and fiber size in neuromuscular disorders

被引：91

作者：

Blijham, P. J.

ter Laak, H. J.

Schelhaas, H. J.

van Engelen, B. G. M.

Stegeman, D. F.

Zwarts, M. J.

机构：

[1] Radboud Univ Nijmegen, Nijmegen Med Ctr, Inst Neurol 920, Dept Clin Neurophysiol, NL-6500 HB Nijmegen, Netherlands

[2] Interuniv Inst Fundamental & Clin Human Movement, Amsterdam, Netherlands

[3] Radboud Univ Nijmegen, Nijmegen Med Ctr, Inst Neurol, Neuromuscular Ctr Nijmegen, NL-6500 HB Nijmegen, Netherlands

[4] Radboud Univ Nijmegen, Nijmegen Med Ctr, Inst Neurol & Pathol, NL-6500 HB Nijmegen, Netherlands

来源：

JOURNAL OF APPLIED PHYSIOLOGY | 2006年 / 100卷 / 06期

关键词：

electromyogram; muscle biopsy; muscle fiber potentials; propagation velocity;

D O I：

10.1152/japplphysiol.01009.2005

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

To determine the relation between muscle fiber conduction velocity (MFCV) and muscle fiber diameter (MFD) in pathological conditions, we correlated invasively measured MFCV values with MFD data obtained from muscle needle biopsies in 96 patients with various neuromuscular disorders. MFCV was significantly correlated with MFD and independent of the underlying disorder. Pathological diameter changes were fiber-type dependent, with corresponding MFCVs. A linear equation expresses the relation well: MFCV (m/s) = 0.043(.)MFD (mu m) + 0.83. We conclude that fiber diameter determines MFCV largely independent of the underlying neuromuscular disorders studied.

引用

页码：1837 / 1841

页数：5

共 15 条

[1] Muscle-fiber conduction velocity and electromyography as diagnostic tools in patients with suspected inflammatory myopathy: A prospective study [J].

Blijham, PJ ;

Hengstman, GJD ;

Ter Laak, HJ ;

Van Engelen, BGM ;

Zwarts, MJ .

MUSCLE & NERVE, 2004, 29 (01) :46-50

[2]

Cruz-Martínez A, 1999, ACTA NEUROL SCAND, V100, P337

[3] CONDUCTION VELOCITIES IN SINGLE FIBERS OF DISEASED HUMAN-MUSCLE [J].

GRUENER, R ;

STERN, LZ ;

WEISZ, RR .

NEUROLOGY, 1979, 29 (09) :1293-1297

[4] CONDUCTION VELOCITY AND AMPLITUDE OF THE ACTION POTENTIAL AS RELATED TO CIRCUMFERENCE IN THE ISOLATED FIBRE OF FROG MUSCLE [J].

HAKANSSON, CH .

ACTA PHYSIOLOGICA SCANDINAVICA, 1956, 37 (01) :14-34

[5] Fibrillation potential amplitude to quantitatively assess denervation muscle atrophy [J].

Jiang, GL ;

Zhang, LY ;

Shen, LY ;

Xu, JG ;

Gu, YD .

NEUROMUSCULAR DISORDERS, 2000, 10 (02) :85-91

[6] THE EQUIVALENT SOURCE DESCRIPTION REPRESENTING THE EXTINCTION OF AN ACTION-POTENTIAL AT A MUSCLE-FIBER ENDING [J].

KLEINPENNING, PH ;

GOOTZEN, THJM ;

VANOOSTEROM, A ;

STEGEMAN, DF .

MATHEMATICAL BIOSCIENCES, 1990, 101 (01) :41-61

[7]

MARTINEZ AC, 1990, ARCH PHYS MED REHAB, V71, P558

[8] SIMULATION OF SINGLE MUSCLE-FIBER ACTION-POTENTIALS [J].

NANDEDKAR, SD ;

STALBERG, E .

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 1983, 21 (02) :158-165

[9] DATA ON FIBER SIZE IN 36 HUMAN MUSCLES - AUTOPSY STUDY [J].

POLGAR, J ;

JOHNSON, MA ;

WEIGHTMAN, D ;

APPLETON, D .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1973, 19 (03) :307-318

[10]

Stalberg E, 1966, Acta Physiol Scand Suppl, V287, P1

← 1 2 →