Synergistic effects of chronic exposure to subthreshold concentrations of quinolinic acid and malonate in the rat striatum

被引：11

作者：

Bazzett, TJ

Falik, RC

Becker, JB

Albin, RL

机构：

[1] UNIV MICHIGAN,NEUROSCI LAB,DEPT PSYCHOL,ANN ARBOR,MI 48104

[2] UNIV MICHIGAN,NEUROSCI LAB,REPROD SCI PROGRAM,ANN ARBOR,MI 48104

[3] UNIV MICHIGAN,NEUROSCI LAB,PROGRAM NEUROSCI,ANN ARBOR,MI 48104

来源：

BRAIN RESEARCH | 1996年 / 718卷 / 1-2期

关键词：

Huntington's disease; excitotoxicity; mitochondria; nitric oxide synthase; NMDA; basal ganglia; chronic administration;

D O I：

10.1016/0006-8993(96)00143-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Adult rats received chronic intrastriatal dialytic exposure to quinolinic acid (QUIN), malonate, or a combination of QUIN and malonate. The combination of subthreshold concentrations of QUIN (4 mM) and malonate (400 mM) produced lesions larger than did either QUIN or malonate alone. Tho neurotoxic effect of QUIN combined with malonate was subsequently blocked by co-administration of the NMDA receptor antagonist MK-801 (1 mM). These findings indicate that: malonate synergistically enhances NMDA receptor mediated excitotoxicity.

引用

页码：228 / 232

页数：5

共 27 条

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