BDNF in the Dentate Gyrus Is Required for Consolidation of "Pattern-Separated" Memories

被引：100

作者：

Bekinschtein, Pedro ^{[1
,2
,3
,4
]}

Kent, Brianne A. ^{[1
,2
,3
,4
]}

Oomen, Charlotte A. ^{[1
,2
,3
,4
]}

Clemenson, Gregory D. ^{[5
]}

Gage, Fred H. ^{[5
]}

Saksida, Lisa M. ^{[1
,2
,3
,4
]}

Bussey, Timothy J. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Cambridge, Dept Psychol, Cambridge 23EB, England

[2] Univ Cambridge, MRC, Cambridge 23EB, England

[3] Univ Cambridge, Wellcome Trust Behav, Cambridge 23EB, England

[4] Univ Cambridge, Clin Neurosci Inst, Cambridge 23EB, England

[5] Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA

来源：

CELL REPORTS | 2013年 / 5卷 / 03期

基金：

英国生物技术与生命科学研究理事会;

关键词：

ENHANCED SYNAPTIC PLASTICITY; GRANULE CELLS; HIPPOCAMPAL NEUROGENESIS; NEUROTROPHIC FACTOR; SPATIAL MEMORY; TERM; INCREASES; LOCATION; VESICLES; STORAGE;

D O I：

10.1016/j.celrep.2013.09.027

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Successful memory involves not only remembering information over time, but also keeping memories distinct and less confusable. The computational process for making representations for similar input patterns more distinct from each other has been referred to as "pattern separation." In this work, we developed a set of behavioral conditions that allowed us to manipulate the load for pattern separation at different stages of memory. Thus, we provide experimental evidence that a brain-derived neurotrophic factor (BDNF)-dependent pattern separation process occurs during the encoding/storage/consolidation, but not the retrieval stage of memory processing. We also found that a spontaneous increase in BDNF in the dentate gyrus of the hippocampus is associated with exposure to landmarks delineating similar, but not dissimilar, spatial locations, suggesting that BDNF is expressed on an "as-needed" basis for pattern separation.

引用

页码：759 / 768

页数：10

共 32 条

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