High-sensitivity negative-ion laser spray for liquid chromatography/mass spectrometry

被引：12

作者：

Hiraoka, K ^{[1
]}

Asakawa, Y ^{[1
]}

Yamamoto, Y ^{[1
]}

Nakamura, M ^{[1
]}

Ueda, K ^{[1
]}

机构：

[1] Yamanashi Univ, Clean Energy Res Ctr, Kofu, Yamanashi 4008511, Japan

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 2001年 / 15卷 / 21期

关键词：

D O I：

10.1002/rcm.473

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A negative-ion mode laser spray interface for use in liquid chromatography/mass spectrometry (LC/MS) has been developed and investigated. The laser spray gave sensitivities that were orders of magnitude better than the negative-ion electrospray for all samples investigated with the exception of sugars. Fragment ions, HSO4- and SO3-, were formed from the laser-sprayed aqueous solution of cholesterol 3-sulfate sodium salt. This suggests that structural information may be obtained directly from the laser-spray mass spectra for thermally labile compounds. Copyright (C) 2001 John Wiley & Sons, Ltd.

引用

页码：2020 / 2026

页数：7

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