The matrilineal ancestry of Ashkenazi Jewry: Portrait of a recent founder event

被引：123

作者：

Behar, DM

Metspalu, E

Kivisild, T

Achilli, A

Hadid, Y

Tzur, S

Pereira, L

Amorim, A

Quintana-Murci, L

Majamaa, K

Herrnstadt, C

Howell, N

Balanovsky, O

Kutuev, I

Pshenichnov, A

Gurwitz, D

Bonne-Tamir, B

Torroni, A

Villems, R

Skorecki, K

机构：

[1] Univ Tartu, Dept Evolutionary Biol, EE-51010 Tartu, Estonia

[2] Techn & Rambam Med Ctr, Rappaport Fac Med, Haifa, Israel

[3] Techn & Rambam Med Ctr, Res Inst, Haifa, Israel

[4] Estonian Bioctr, Tartu, Estonia

[5] Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy

[6] Univ Porto, Inst Patol & Immunol Mol, P-4100 Oporto, Portugal

[7] Univ Porto, Fac Ciencias, P-4100 Oporto, Portugal

[8] Inst Pasteur, CNRS, FRE 2849, Unit Mol Prevent & Therapy Human Dis, Paris, France

[9] Univ Turku, Dept Neurol, Turku, Finland

[10] MitoKor Inc, San Diego, CA USA

[11] Russian Acad Med Sci, Med Genet Res Ctr, Moscow, Russia

[12] Russian Acad Sci, Inst Biochem & Genet, Ufa Res Ctr, Ufa 450001, Russia

[13] Tel Aviv Univ, Sackler Fac Med, Dept Human Genet & Mol Med, IL-69978 Tel Aviv, Israel

来源：

AMERICAN JOURNAL OF HUMAN GENETICS | 2006年 / 78卷 / 03期

基金：

美国国家科学基金会; 以色列科学基金会;

关键词：

D O I：

10.1086/500307

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Both the extent and location of the maternal ancestral deme from which the Ashkenazi Jewry arose remain obscure. Here, using complete sequences of the maternally inherited mitochondrial DNA ( mtDNA), we show that close to one-half of Ashkenazi Jews, estimated at 8,000,000 people, can be traced back to only 4 women carrying distinct mtDNAs that are virtually absent in other populations, with the important exception of low frequencies among non-Ashkenazi Jews. We conclude that four founding mtDNAs, likely of Near Eastern ancestry, underwent major expansion(s) in Europe within the past millennium.

引用

页码：487 / 497

页数：11

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[1] The molecular dissection of mtDNA haplogroup H confirms that the Franco-Cantabrian glacial refuge was a major source for the European gene pool [J].