Prescription of drugs to pregnant women in France: the HIMAGE study

被引:30
作者
Beyens, MN [1 ]
Guy, C [1 ]
Ratrema, M [1 ]
Ollagnier, M [1 ]
机构
[1] Hop Bellevue, Ctr Reg Pharmacovigilance, F-42055 St Etienne 2, France
来源
THERAPIE | 2003年 / 58卷 / 06期
关键词
prescription; pregnancy; drugs; pharmacovigilance; pharmacoepidemiology; EXPOSURE; POPULATION; RECALL;
D O I
10.2515/therapie:2003082
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The HIMAGE study, conducted in partnership with the principal Public Health Insurance Funds of the Loire region, analysed medicinal prescriptions during pregnancy on the basis of a representative sample of 911 pregnant women resident in this region of France. Altogether 93.5% received at least one prescription, with a mean of 10.9 different drugs per woman. The prescriptions were predominantly for drugs of the following Anatomical Therapeutic Chemical (ATC) classes: "alimentary tract and metabolism" (78%); "genito-urinary system and sex hormones" (62%); "nervous system" (62%); and "blood and blood-forming organs" (57%). Iron supplements, paracetamol, folic acid, magnesium, progesterone, oxaceprol, phloroglucinol, amoxicillin, domperidone and diosmine were the most frequently prescribed drugs. In total, 4.6% of the women were exposed to drugs involving a risk during pregnancy: principally nonsteroidal anti-inflammatory drugs (NSAIDs) prescribed from the sixth month onwards. This study revealed a high frequency of prescription of drugs to pregnant women, largely motivated by non-rational and to some extent culture-specific considerations, and it also highlighted the prescription of drugs known to involve risk during pregnancy. These results provide a basis for advising clinicians on the rational and safe use of drugs during pregnancy.
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页码:505 / 511
页数:7
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