The Different Facets of Extracellular Calcium Sensors: Old and New Concepts in Calcium-Sensing Receptor Signalling and Pharmacology

被引：51

作者：

Gerbino, Andrea ^{[1
]}

Colella, Matilde ^{[1
]}

机构：

[1] Univ Bari, Dept Biosci Biotechnol & Biopharmaceut, I-70121 Bari, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 04期

关键词：

Ca2+-signalling; microelectrode; fluorophore; exocytosis; cAMP signalling; parathyroid extracellular-Ca2+-sensing receptor (CaR); cancer; apoptosis; ischemia/reperfusion; hypertrophy; heart; cardiomyocytes; METABOTROPIC GLUTAMATE-RECEPTOR; HUMAN CA2+ RECEPTOR; PROTEIN-COUPLED RECEPTORS; NITRIC-OXIDE PRODUCTION; PARATHYROID-HORMONE RELEASE; CELL-SURFACE EXPRESSION; LOSS-OF-FUNCTION; CA2+-SENSING RECEPTOR; DIVALENT-CATIONS; STRONTIUM RANELATE;

D O I：

10.3390/ijms19040999

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The current interest of the scientific community for research in the field of calcium sensing in general and on the calcium-sensing Receptor (CaR) in particular is demonstrated by the still increasing number of papers published on this topic. The extracellular calcium-sensing receptor is the best-known G-protein-coupled receptor (GPCR) able to sense external Ca2+ changes. Widely recognized as a fundamental player in systemic Ca2+ homeostasis, the CaR is ubiquitously expressed in the human body where it activates multiple signalling pathways. In this review, old and new notions regarding the mechanisms by which extracellular Ca2+ microdomains are created and the tools available to measure them are analyzed. After a survey of the main signalling pathways triggered by the CaR, a special attention is reserved for the emerging concepts regarding CaR function in the heart, CaR trafficking and pharmacology. Finally, an overview on other Ca2+ sensors is provided.

引用

页数：37

共 323 条

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