Plasma adiponectin concentrations do not increase in association with moderate weight loss in insulin-resistant, obese women

被引：47

作者：

Abbasi, F

Lamendola, C

McLaughlin, T

Hayden, J

Reaven, GM

Reaven, PD

机构：

[1] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA

[2] Dept Vet Affairs, Dept Med, Phoenix, AZ USA

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2004年 / 53卷 / 03期

关键词：

D O I：

10.1016/j.metabol.2003.10.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Plasma adiponectin concentrations were measured before and after moderate weight loss in 20 obese women, divided at baseline into insulin-resistant (IR) and insulin-sensitive (IS) subgroups on the basis of their steady-state plasma glucose (SSPG) concentration at the end of a 180-minute infusion of octreotide, glucose, and insulin. The groups were similar in age and body weight and lost comparable amounts of weight (8 to 9 kg) during the weight loss period. Fasting plasma insulin and SSPG concentrations were significantly higher (P < .001) and adiponectin concentrations somewhat lower (P = .10) in the IR group (P < .001) at baseline. Both SSPG and plasma insulin concentrations decreased in IR subjects (P < .001), but did not change in IS individuals. Adiponectin concentrations did not change with weight loss in either group. Thus, neither weight loss, per se, nor enhanced insulin sensitivity resulted in a change in plasma adiponectin concentrations. (C) 2004 Elsevier Inc. All rights reserved.

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页码：280 / 283

页数：4

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