Novel lipoxygenase inhibitors, tetrapetalone B, C, and D from Streptomyces sp.

被引：43

作者：

Komoda, T ^{[1
]}

Kishi, M ^{[1
]}

Abe, N ^{[1
]}

Sugiyama, Y ^{[1
]}

Hirota, A ^{[1
]}

机构：

[1] Univ Shizuoka, Sch Food & Nutrit Sci, Appl Microbiol Lab, Shizuoka 4228526, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2004年 / 68卷 / 04期

关键词：

soybean lipoxygenase inhibitor; Streptomyces; tetrapetalone;

D O I：

10.1271/bbb.68.903

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Three novel lipoxygenase inhibitors, tetrapetalone B (2, C28H35NO9), C (3, C26H34NO8), and D (4, C28H36NO10), were isolated from a culture broth of Streptomyces sp. USF-4727 that produced a lipoxygenase inhibitor tetrapetalone A (1) simultaneously. Each chemical structure was revealed by spectroscopic evidence, this suggests that these three compounds are structurally related to 1. They had a tetracyclic skeleton and a beta-D-rhodinosyl moiety. Tetrapetalone B, C, and D inhibited soybean lipoxygenase with IC50: 320, 360, and 340 mum respectively.

引用

页码：903 / 908

页数：6

共 7 条

[1]

THE DISCOVERY AND DEVELOPMENT OF ZILEUTON - AN ORALLY ACTIVE 5-LIPOXYGENASE INHIBITOR [J].

BELL, RL ;

YOUNG, PR ;

ALBERT, D ;

LANNI, C ;

SUMMERS, JB ;

BROOKS, DW ;

RUBIN, P ;

CARTER, GW .

INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, 1992, 14 (03) :505-510

[2]

Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells [J].

Ghosh, J ;

Myers, CE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (22) :13182-13187

[3]

Tetrapetalone A, a novel lipoxygense inhibitor from Streptomyces sp. [J].

Komoda, T ;

Yoshida, K ;

Abe, N ;

Sugiyama, Y ;

Imachi, M ;

Hirota, H ;

Koshino, H ;

Hirota, A .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2004, 68 (01) :104-111

[4]

Revised structure of tetrapetalone A and its absolute stereochemistry [J].

Komoda, T ;

Sugiyama, Y ;

Abe, N ;

Imachi, M ;

Hirota, H ;

Koshino, H ;

Hirota, A .

TETRAHEDRON LETTERS, 2003, 44 (40) :7417-7419

[5]

Tetrapetalone A, a novel lipoxygenase inhibitor from Streptomyces sp. [J].

Komoda, T ;

Sugiyama, Y ;

Abe, N ;

Imachi, M ;

Hirota, H ;

Hirota, A .

TETRAHEDRON LETTERS, 2003, 44 (08) :1659-1661

[6]

Komoda Toshikazu, 1995, Bioscience Biotechnology and Biochemistry, V59, P924

[7]

LEUKOTRIENES - MEDIATORS OF IMMEDIATE HYPERSENSITIVITY REACTIONS AND INFLAMMATION [J].

SAMUELSSON, B .

SCIENCE, 1983, 220 (4597) :568-575

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