A new methodology for the preparation of 2-cyanopyrroles and synthesis of porphobilinogen

被引：20

作者：

Adamczyk, M

Reddy, RE

机构：

[1] Div. Organ. Chem. Res. (9NM, AP20), Diagnostic Division, Abbott Laboratories, Abbott Park, IL 60064-3500

来源：

TETRAHEDRON | 1996年 / 52卷 / 47期

关键词：

D O I：

10.1016/0040-4020(96)00941-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Condensation of alpha-acetoxynitro compounds 4a-f with isocyanoacetonitrile (5) using DBU in THF afforded 2-cyono-3,4-substituted pyrroles 6a-f, in good yield. Porphobilinogen (PBG, 12), the key building block for the preparation of tetrapyrrolic natural products, was synthesized from 2-cyano-3,4-substituted pyrrole 6f, in four steps. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：14689 / 14700

页数：12

共 94 条

[1] A CONVENIENT AND VERSATILE SYNTHESIS OF PORPHOBILINOGEN [J].