Therapeutic angiogenesis for heart failure

被引:103
作者
Isner, JM [1 ]
Losordo, DW
机构
[1] Tufts Univ, Sch Med, St Elizabeths Med Ctr, Dept Med Cardiol Vasc Med, Boston, MA 02111 USA
[2] Tufts Univ, Sch Med, St Elizabeths Med Ctr, Dept Biomed Res, Boston, MA 02111 USA
[3] St Elizabeths Med Ctr, Boston, MA 02135 USA
关键词
D O I
10.1038/8374
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A new study answers one set of questions, but raises many more, about the potential use of specific VEGF isoforms to promote re-vascularization for ischemic cardiomyopathy (pages 495-502).
引用
收藏
页码:491 / 492
页数:2
相关论文
共 14 条
[1]   Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia [J].
Baumgartner, I ;
Pieczek, A ;
Manor, O ;
Blair, R ;
Kearney, M ;
Walsh, K ;
Isner, JM .
CIRCULATION, 1998, 97 (12) :1114-1123
[2]   Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele [J].
Carmeliet, P ;
Ferreira, V ;
Breier, G ;
Pollefeyt, S ;
Kieckens, L ;
Gertsenstein, M ;
Fahrig, M ;
Vandenhoeck, A ;
Harpal, K ;
Eberhardt, C ;
Declercq, C ;
Pawling, J ;
Moons, L ;
Collen, D ;
Risau, W ;
Nagy, A .
NATURE, 1996, 380 (6573) :435-439
[3]   Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene [J].
Ferrara, N ;
CarverMoore, K ;
Chen, H ;
Dowd, M ;
Lu, L ;
OShea, KS ;
PowellBraxton, L ;
Hillan, KJ ;
Moore, MW .
NATURE, 1996, 380 (6573) :439-442
[4]   VEGF improves myocardial blood flow but produces EDRF-mediated hypotension in porcine hearts [J].
Hariawala, MD ;
Horowitz, JR ;
Esakof, D ;
Sheriff, DD ;
Walter, D ;
Keyt, B ;
Isner, JM ;
Symes, JF .
JOURNAL OF SURGICAL RESEARCH, 1996, 63 (01) :77-82
[5]  
HOUCK KA, 1992, J BIOL CHEM, V267, P26031
[6]   Clinical evidence of angiogenesis after arterial gene transfer of phVEGF(165) in patient with ischaemic limb [J].
Isner, JM ;
Pieczek, A ;
Schainfeld, R ;
Blair, R ;
Haley, L ;
Asahara, T ;
Rosenfield, K ;
Razvi, S ;
Walsh, E ;
Symes, JF .
LANCET, 1996, 348 (9024) :370-374
[7]   Treatment of thromboangiitis obliterans (Buerger's disease) by intramuscular gene transfer of vascular endothelial growth factor: Preliminary clinical results [J].
Isner, JM ;
Baumgartner, I ;
Rauh, G ;
Schainfeld, R ;
Blair, R ;
Manor, O ;
Razvi, S ;
Symes, JF .
JOURNAL OF VASCULAR SURGERY, 1998, 28 (06) :964-973
[8]   Gene therapy for myocardial angiogenesis -: Initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia [J].
Losordo, DW ;
Vale, PR ;
Symes, JF ;
Dunnington, CH ;
Esakof, DD ;
Maysky, M ;
Ashare, AB ;
Lathi, K ;
Isner, JM .
CIRCULATION, 1998, 98 (25) :2800-2804
[9]   Biologic bypass with the use of adenovirus-mediated gene transfer of the complementary deoxyribonucleic acid for vascular endothelial growth factor 121 improves myocardial perfusion and function in the ischemic porcine heart [J].
Mack, CA ;
Patel, SR ;
Schwarz, EA ;
Zanzonico, P ;
Hahn, RT ;
Ilercil, A ;
Devereux, RB ;
Goldsmith, SJ ;
Christian, TF ;
Sanborn, TA ;
Kovesdi, I ;
Hackett, N ;
Isom, OW ;
Crystal, RG ;
Rosengart, TK .
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 1998, 115 (01) :168-176
[10]   MAGNETIC-RESONANCE MAPPING DEMONSTRATES BENEFITS OF VEGF INDUCED MYOCARDIAL ANGIOGENESIS [J].
PEARLMAN, JD ;
HIBBERD, MG ;
CHUANG, ML ;
HARADA, K ;
LOPEZ, JJ ;
GLADSTONE, SR ;
FRIEDMAN, M ;
SELLKE, FW ;
SIMONS, M .
NATURE MEDICINE, 1995, 1 (10) :1085-1089