New anti-HSV therapeutics target the helicase primase complex

被引：40

作者：

Crumpacker, CS ^{[1
]}

Schaffer, PA

机构：

[1] Harvard Univ, Sch Med, Dept Med, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA

[3] Beth Israel Deaconess Med Ctr, Div Infect Dis, Boston, MA 02215 USA

来源：

NATURE MEDICINE | 2002年 / 8卷 / 04期

关键词：

D O I：

10.1038/nm0402-327

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The only targets for clinical treatment of herpes simplex virus infections have been the viral enzymes thymidine kinase and DNA polymerase. Now, animal experiments show the healing benefits of new antiherpes drugs that act on the viral helicase–primase complex and appear superior to the standard treatment, acyclovir.

引用

页码：327 / 328

页数：2

共 11 条

[1] Herpes simplex virus DNA replication [J].

Boehmer, PE ;

Lehman, IR .

ANNUAL REVIEW OF BIOCHEMISTRY, 1997, 66 :347-384

[2] 2 DISTINCT LOCI CONFER RESISTANCE TO ACYCLOGUANOSINE IN HERPES-SIMPLEX VIRUS TYPE-1 [J].

COEN, DM ;

SCHAFFER, PA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (04) :2265-2269

[3]

CRUTE JJ, 1991, J BIOL CHEM, V266, P4484

[4] Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease [J].

Crute, JJ ;

Grygon, CA ;

Hargrave, KD ;

Simoneau, B ;

Faucher, AM ;

Bolger, G ;

Kibler, P ;

Liuzzi, M ;

Cordingley, MG .

NATURE MEDICINE, 2002, 8 (04) :386-391

[5] SELECTIVITY OF ACTION OF AN ANTI-HERPETIC AGENT, 9-(2-HYDROXYETHOXYMETHYL)GUANINE [J].

ELION, GB ;

FURMAN, PA ;

FYFE, JA ;

DEMIRANDA, P ;

BEAUCHAMP, L ;

SCHAEFFER, HJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) :5716-5720

[6] INHIBITION OF HERPES-SIMPLEX VIRUS-INDUCED DNA-POLYMERASE ACTIVITY AND VIRAL-DNA REPLICATION BY 9-(2-HYDROXYETHOXYMETHYL)GUANINE AND ITS TRIPHOSPHATE [J].

FURMAN, PA ;

STCLAIR, MH ;

FYFE, JA ;

RIDEOUT, JL ;

KELLER, PM ;

ELION, GB .

JOURNAL OF VIROLOGY, 1979, 32 (01) :72-77

[7] New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease [J].

Kleymann, G ;

Fischer, R ;

Betz, UAK ;

Hendrix, M ;

Bender, W ;

Schneider, U ;

Handke, G ;

Eckenberg, P ;

Hewlett, G ;

Pevzner, V ;

Baumeister, J ;

Weber, O ;

Henninger, K ;

Keldenich, J ;

Jensen, A ;

Kolb, J ;

Bach, U ;

Popp, A ;

Mäben, J ;

Frappa, I ;

Haebich, D ;

Lockhoff, O ;

Rübsamen-Waigmann, H .

NATURE MEDICINE, 2002, 8 (04) :392-398

[8] A CONTROLLED TRIAL COMPARING FOSCARNET WITH VIDARABINE FOR ACYCLOVIR-RESISTANT MUCOCUTANEOUS HERPES-SIMPLEX IN THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME [J].

SAFRIN, S ;

CRUMPACKER, C ;

CHATIS, P ;

DAVIS, R ;

HAFNER, R ;

RUSH, J ;

KESSLER, HA ;

LANDRY, B ;

MILLS, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1991, 325 (08) :551-555

[9] RESISTANCE OF HERPES-SIMPLEX VIRUS TO ACYCLOGUANOSINE - ROLE OF VIRAL THYMIDINE KINASE AND DNA-POLYMERASE LOCI [J].

SCHNIPPER, LE ;

CRUMPACKER, CS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (04) :2270-2273

[10] Inhibition of herpes simplex virus replication by a 2-amino thiazole via interactions with the helicase component of the UL5-UL8-UL52 complex [J].

Spector, FC ;

Liang, L ;

Giordano, H ;

Sivaraja, M ;

Peterson, MG .

JOURNAL OF VIROLOGY, 1998, 72 (09) :6979-6987

← 1 2 →