HBZ interacts with JunD and stimulates its transcriptional activity

被引：107

作者：

Thébault, S ^{[1
]}

Basbous, J ^{[1
]}

Hivin, P ^{[1
]}

Devaux, C ^{[1
]}

Mesnard, JM ^{[1
]}

机构：

[1] CNRS, Lab Infect Retrovirales & Signalisat Cellulaire, UM 1 UMR 5121, IFR 122,Inst Biol, F-34960 Montpellier 2, France

来源：

FEBS LETTERS | 2004年 / 562卷 / 1-3期

关键词：

human T-cell leukemia virus type I; basic leucine zipper factor; human T-cell leukemia virus type I basic leucine zipper; activator protein-1; JunD;

D O I：

10.1016/S0014-5793(04)00225-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human T-cell leukemia virus type I (HTLV-I) bZIP factor (HBZ) is a viral basic leucine zipper protein that was originally described as a partner of cAMP response element binding protein-2 and as a repressor of HTLV-I viral transcription. In addition, HBZ is able to interact with the activator protein-1 (AP-1) transcription factors c-Jun and JunB, the interaction with c-Jun leading to a transcriptional repression of AP-1-regulated genes. Here we show that HBZ also interacts with JunD in vitro and in vivo, and that this association occurs via the bZIP domain of the two proteins. Moreover, we show that HBZ can activate JunD-dependent transcription and that its amino-terminus is required. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：165 / 170

页数：6

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