Synthesis and HIV-1 integrase inhibitory activities of catechol and bis-catechol derivatives

被引：35

作者：

Dupont, R

Jeanson, L

Mouscadet, JF

Cotelle, P ^{[1
]}

机构：

[1] Univ Sci & Tech Lille Flandres Artois, UPRESA CNRS 8009, Chim Organ Phys Lab, F-59655 Villeneuve Dascq, France

[2] Inst Gustave Roussy, UMR CNRS 8532, Lab Physicochim & Pharmacol Macromol Biol, PRII, F-94805 Villejuif, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(01)00658-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Fourteen catechol and bis-catechol derivatives have been synthesised and tested for their HIV-1 inhibitory activities. The six more active molecules have been tested for their antiviral activity and cytotoxicity. We have found that bis-catechols 1 and 2 are the most active HIV-1 integrase inhibitor whereas the best antiviral compound is 4. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：3175 / 3178

页数：4

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