Gabapentin-induced neurologic toxicities

被引：24

作者：

Bookwalter, T ^{[1
]}

Gitlin, M ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Pharmaceut Sci, San Francisco, CA 94143 USA

来源：

PHARMACOTHERAPY | 2005年 / 25卷 / 12期

关键词：

neurontin; gabapentin; myoclonus; asterixis; renal failure; neurologic toxicity; adverse effects;

D O I：

10.1592/phco.2005.25.12.1817

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Gabapentin is an antiepileptic drug approved for the treatment of postherpetic neuralgia and as adjunctive therapy for partial seizures. The drug has been shown to be safe and nontoxic. The current literature has limited reports of neurologic toxicity associated with gabapentin therapy in patients with or without renal dysfunction. We describe the case of a 75-year-old man with renal dysfunction who developed neurologic toxicity due to gabapentin accumulation. Future studies are warranted to confirm the neurologic adverse effects of gabapentin, including any additional risks in patients with renal dysfunction.

引用

页码：1817 / 1819

页数：3

共 14 条

[1] Myoclonus associated with the use of gabapentin [J].

Asconapé, J ;

Diedrich, A ;

DellaBadia, J .

EPILEPSIA, 2000, 41 (04) :479-481

[2] Gabapentin neurotoxicity in a chronic haemodialysis patient [J].

Bassilios, N ;

Launay-Vacher, V ;

Khoury, N ;

Rondeau, E ;

Deray, G ;

Sraer, JD .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2001, 16 (10) :2112-2113

[3] PHARMACOKINETICS OF GABAPENTIN IN SUBJECTS WITH VARIOUS DEGREES OF RENAL-FUNCTION [J].

BLUM, RA ;

COMSTOCK, TJ ;

SICA, DA ;

SCHULTZ, RW ;

KELLER, E ;

REETZE, P ;

BOCKBRADER, H ;

TUERCK, D ;

BUSCH, JA ;

REECE, PA ;

SEDMAN, AJ .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1994, 56 (02) :154-159

[4] Asterixis induced by gabapentin [J].

Jacob, PC ;

Chand, RP ;

Omeima, ES .

CLINICAL NEUROPHARMACOLOGY, 2000, 23 (01) :53-53

[5] Gabapentin toxicity requiring intubation in a patient receiving long-term hemodialysis [J].

Jones, H ;

Aguila, E ;

Farber, HW .

ANNALS OF INTERNAL MEDICINE, 2002, 137 (01) :74-75

[6] Characterization of gabapentin overdose using a poison center case series [J].

Klein-Schwartz, W ;

Shepherd, JG ;

Gorman, S ;

Dahl, B .

JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY, 2003, 41 (01) :11-15

[7] Gabapentin-related dyskinesia [J].

Norton, JW ;

Quarles, E .

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2001, 21 (06) :623-624

[8]

PARKEDAVIS, 1993, NEURONTIN GABAPENTIN

[9] Gabapentin-induced hypoglycemia in a long-term peritoneal dialysis patient [J].

Penumalee, S ;

Kissner, PZ ;

Migdal, SD .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2003, 42 (06)

[10] Asterixis and toxic encephalopathy induced by gabapentin [J].

Sechi, G ;

Murgia, B ;

Sau, G ;

Peddone, L ;

Tirotto, A ;

Barrocu, M ;

Rosati, G .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2004, 28 (01) :195-199

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