Synthesis and cytotoxic activity of tetracenomycin D and of saintopin analogues

被引：16

作者：

Martin, P

Rodier, S

Mondon, M

Renoux, B

Pfeiffer, B

Renard, P

Pierré, A

Gesson, JP

机构：

[1] Univ Poitiers, Lab Synth & React Subst Nat, F-86022 Poitiers, France

[2] CNRS, F-86022 Poitiers, France

[3] ADIR, F-92415 Courbevoie, France

[4] Inst Rech Servier, F-92450 Suresnes, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2002年 / 10卷 / 02期

关键词：

D O I：

10.1016/S0968-0896(01)00273-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regiospecific synthesis of title compounds is based either on cycloaddition of ketene acetals derived from Hagemann's ester or of homophthalic anhydrides. Thus, tetracenomycin D and 3,8-di-O-methyl saintopin have been prepared in few steps. New derivatives of 10-deoxysaintopin have been also obtained. Evaluation of their cytotoxicity against L1210 leukemia cells are reported. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：253 / 260

页数：8

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