Tissue inflammatory response in subacute sclerosing panencephalitis (SSPE)

被引：39

作者：

Anlar, B ^{[1
]}

Söylemezoglu, F

Aysun, S

Köse, G

Belen, D

Yalaz, K

机构：

[1] Hacettepe Univ, Fac Med, Dept Pediat Neurol, TR-06100 Ankara, Turkey

[2] Hacettepe Univ, Fac Med, Dept Pathol, TR-06100 Ankara, Turkey

[3] SSK Ankara Hosp, Dept Pediat Neurol, Ankara, Turkey

[4] SSK Ankara Hosp, Dept Neurosurg, Ankara, Turkey

来源：

JOURNAL OF CHILD NEUROLOGY | 2001年 / 16卷 / 12期

关键词：

D O I：

10.1177/088307380101601206

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The pattern of inflammatory infiltration was studied in the frontal brain biopsies of 28 cases with subacute sclerosing panencephalitis (SSPE) by immunohistochemistry. Lymphocytic infiltration and gliosis were common pathologic findings. CD4+ T lymphocytes were often observed in perivascular areas and CD8+ lymphocytes in the parenchyma. B lymphocytes were located in large perivascular cuffs associated with longer and slower disease. Major histocompatibility complex antigens, interferon-gamma, and tumor necrosis factor-alpha (TNF-alpha) were expressed in endothelial and glial cells. The inflammatory lesions in subacute sclerosing panencephalitis consist of various cell subtypes and cytokines localized in particular areas of the brain tissue and show certain associations with clinical course.

引用

页码：895 / 900

页数：6

共 26 条

[1] Significance of measles virus antigen and genome distribution in the CNS in SSPE for mechanisms of viral spread and demyelination [J].

Allen, IV ;

McQuaid, S ;

McMahon, J ;

Kirk, J ;

McConnell, R .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1996, 55 (04) :471-480

[2] Apoptosis in brain biopsies of subacute sclerosing panencephalitis patients [J].

Anlar, B ;

Söylemezoglu, F ;

Elibol, B ;

Dalkara, T ;

Aysun, S ;

Köse, G ;

Belen, D ;

Yalaz, K .

NEUROPEDIATRICS, 1999, 30 (05) :239-242

[3] MRI findings in subacute sclerosing panencephalitis [J].

Anlar, B ;

Saatci, I ;

Kose, G ;

Yalaz, K .

NEUROLOGY, 1996, 47 (05) :1278-1283

[4] Nucleotide sequences of the matrix protein gene of subacute sclerosing panencephalitis viruses compared with local contemporary isolates from patients with acute measles [J].

Ayata, M ;

Kimoto, T ;

Hayashi, K ;

Seto, T ;

Murata, R ;

Ogura, H .

VIRUS RESEARCH, 1998, 54 (01) :107-115

[5] CELL-MEDIATED-IMMUNITY IN PATIENTS WITH SUBACUTE SCLEROSING PANENCEPHALITIS [J].

AYSUN, S ;

SANAL, O ;

RENDA, Y ;

BERKEL, I ;

YALAZ, K ;

ERSOY, F ;

OZDIRIM, E .

BRAIN & DEVELOPMENT, 1984, 6 (04) :391-396

[6]

Bitsch A, 2000, GLIA, V29, P366, DOI 10.1002/(SICI)1098-1136(20000215)29:4<366::AID-GLIA7>3.0.CO

[7]

2-Y

[8] High-dose methylprednisolone reduces cytokine-induced adhesion molecules on human brain endothelium [J].

Gelati, M ;

Corsini, E ;

Dufour, A ;

Massa, G ;

Giombini, S ;

Solero, CL ;

Salmaggi, A .

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 2000, 27 (03) :241-244

[9] Major histocompatibility complex class I expression on neurons in subacute sclerosing panencephalitis and experimental subacute measles encephalitis [J].

Gogate, N ;

Swoveland, P ;

Yamabe, T ;

Verma, L ;

Woyciechowska, J ;

TarnowskaDziduszko, E ;

Dymecki, J ;

DhibJalbut, S .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1996, 55 (04) :435-443

[10] Neuroprotection by encephalomyelitis:: Rescue of mechanically injured neurons and neurotrophin production by CNS-infiltrating T and natural killer cells [J].

Hammarberg, H ;

Lidman, O ;

Lundberg, C ;

Eltayeb, SY ;

Gielen, AW ;

Muhallab, S ;

Svenningsson, A ;

Lindå, H ;

van der Meide, PH ;

Cullheim, S ;

Olsson, T ;

Piehl, F .

JOURNAL OF NEUROSCIENCE, 2000, 20 (14) :5283-5291

← 1 2 3 →