METHOD OF THE YEAR Quantitative analysis of peptides and proteins in biomedicine by targeted mass spectrometry

被引：366

作者：

Gillette, Michael A. ^{[1
,2
]}

Carr, Steven A. ^{[1
]}

机构：

[1] Broad Inst Massachusetts Inst Technol & Harvard, Cambridge, MA USA

[2] Massachusetts Gen Hosp, Boston, MA 02114 USA

来源：

NATURE METHODS | 2013年 / 10卷 / 01期

关键词：

ASSAY DEVELOPMENT; BIOMARKER; QUANTIFICATION; PLASMA; DISCOVERY; VERIFICATION; PIPELINE; VALIDATION; ENRICHMENT; PLATFORMS;

D O I：

10.1038/nmeth.2309

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Targeted mass spectrometry (MS) is becoming widely used in academia and in pharmaceutical and biotechnology industries for sensitive and quantitative detection of proteins, peptides and post-translational modifications. Here we describe the increasing importance of targeted MS technologies in clinical proteomics and the potential key roles these techniques will have in bridging biomedical discovery and clinical implementation.

引用

页码：28 / 34

页数：7

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