NMR spectroscopy of large molecules and multimolecular assemblies in solution

被引：164

作者：

Wider, G ^{[1
]}

Wüthrich, K ^{[1
]}

机构：

[1] ETH Honggerberg, Inst Mol Biol & Biophys, CH-8093 Zurich, Switzerland

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1999年 / 9卷 / 05期

关键词：

D O I：

10.1016/S0959-440X(99)00011-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New strategies and technical advances in NMR spectroscopy and biochemical methods for isotope labeling have enabled solution NMR studies of biomacromolecular systems of 100 kDa and larger. Recent progress has been made, in particular, with techniques for sequential resonance assignments, novel approaches for the direct observation of hydrogen bonds in nucleic acids and proteins, and segmental isotope labeling.

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页码：594 / 601

页数：8

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