Bromophycolides C-I from the Fijian red alga Callophycus serratus

被引：40

作者：

Kubanek, Julia ^{[1
]}

Prusak, Anne C.

Snell, Terry W.

Giese, Rachel A.

Fairchild, Craig R.

Aalbersberg, William

Hay, Mark E.

机构：

[1] Georgia Inst Technol, Sch Biol, Atlanta, GA 30332 USA

[2] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA

[3] Bristol Myers Squibb Pharmaceut Res Inst, Princeton, NJ 08543 USA

[4] Univ S Pacific, Inst Appl Sci, Suva, Fiji

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 05期

关键词：

D O I：

10.1021/np050463o

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bromophycolides C-I ( 1-7) were isolated from extracts of the Fijian red alga Callophycus serratus and identified by NMR and mass spectral techniques. These novel natural products share a carbon skeleton and biosynthetic origin with previously identified bromophycolides A ( 8) and B ( 9), which form a rare group of diterpene-benzoate macrolides. Bromophycolides C-I ( 1-7) displayed modest antineoplastic activity against a range of human tumor cell lines.

引用

页码：731 / 735

页数：5

共 8 条

[1] Marine natural products [J].

Blunt, JW ;

Copp, BR ;

Munro, MHG ;

Northcote, PT ;

Prinsep, MR .

NATURAL PRODUCT REPORTS, 2005, 22 (01) :15-61

[2] The role of vanadium bromoperoxidase in the biosynthesis of halogenated marine natural products [J].

Butler, A ;

Carter-Franklin, JN .

NATURAL PRODUCT REPORTS, 2004, 21 (01) :180-188

[3] Antineoplastic diterpene-benzoate macrolides from the Fijian red alga Callophycus serratus [J].

Kubanek, J ;

Prusak, AC ;

Snell, TW ;

Giese, RA ;

Hardcastle, KI ;

Fairchild, CR ;

Aalbersberg, W ;

Raventos-Suarez, C ;

Hay, ME .

ORGANIC LETTERS, 2005, 7 (23) :5261-5264

[4]

Lee FYF, 2001, CLIN CANCER RES, V7, P1429

[5]

Littler D. S., 2003, S PACIFIC REEF PLANT

[6] New frontiers in biological halogenation [J].

Murphy, CD .

JOURNAL OF APPLIED MICROBIOLOGY, 2003, 94 (04) :539-548

[7]

Silverstein R.M., 1998, SPECTROMETRIC IDENTI, VVI

[8]

SNELL TW, 2005, SMALL SCALE FRESHWAT

← 1 →