Gender- and race-specific determination of albumin excretion rate using albumin-to-creatinine ratio in single, untimed urine specimens - The Coronary Artery Risk Development in Young Adults Study

被引:105
作者
Jacobs, DR
Murtaugh, MA
Steffes, M
Yu, XH
Roseman, J
Goetz, FC
机构
[1] Univ Minnesota, Div Epidemiol, Sch Publ Hlth, Minneapolis, MN 55454 USA
[2] Univ Oslo, Inst Nutr Res, Oslo, Norway
[3] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA
[4] Univ Alabama, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA
关键词
albumins; creatine; urine;
D O I
10.1093/aje/155.12.1114
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Although albumin excretion rate is commonly estimated by using albumin/creatinine ratio (A/C), gender and race differences in creatinine excretion may bias this estimate. The authors optimize the use of an untimed (spot) urine specimen among 3,371 Blacks and Whites aged 28-40 years in the Coronary Artery Risk Development in Young Adults Study in 1995-1996. Using three 24-hour collections during the year 5 examination, they determined k = 0.68 x 0.88 in Black men, 0.88 in Black women, 0.68 in White men, and 1.0 in White women to reflect gender and race differences in creatinine excretion. The authors then computed A/C adjusted for race and sex differences in creatinine excretion (A/kC) by using an untimed urine sample in the year 10 examination. A/kC greater than or equal to 25 mg/g (194 cases of microalbuminuria and 26 cases of clinical grade albuminuria) was more common among Blacks (9.1%) than among Whites (4.2%) and among men (8.2%) than among women (5.0%). Use of the unadjusted A/C underestimated the prevalence of microalbuminuria among men by 52% and among Blacks by 26%. Adjustment of A/C permitted more accurate estimation of albumin excretion rate. Men and Blacks have a higher albumin excretion rate than do women and Whites and may thereby have an increased risk of microvascular and macrovascular disease.
引用
收藏
页码:1114 / 1119
页数:6
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