Catalytic asymmetric addition of alcohols to imines:: Enantioselective preparation of chiral N,O-aminals

被引：160

作者：

Li, Guilong ^{[1
]}

Fronczek, Frank R. ^{[2
]}

Antilla, Jon C. ^{[1
]}

机构：

[1] Univ S Florida, Dept Chem, Tampa, FL 33620 USA

[2] Louisiana State Univ, Dept Chem, Xray Lab, Baton Rouge, LA 70803 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 37期

关键词：

D O I：

10.1021/ja8033334

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The enantioselective addition of alcohols to imine electrophiles has been shown to proceed in the presence of a catalytic amount of a chiral phosphoric acid catalyst. The reaction allows for the formation of the respective chiral N,O-aminals in excellent yield and enantioselectivity. A total of 11 different alcohols and 11 different imines were successfully used as a clear demonstration of the reaction generality.

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页码：12216 / +

页数：3

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