Epstein-Barr Virus in Systemic Lupus Erythematosus, Rheumatoid Arthritis and Multiple Sclerosis-Association and Causation

被引：95

作者：

Lossius, Andreas ^{[1
]}

Johansen, Jorunn N. ^{[1
]}

Torkildsen, Oivind ^{[2
]}

Vartdal, Frode ^{[1
,4
]}

Holmoy, Trygve ^{[3
,4
]}

机构：

[1] Oslo Univ Hosp, Inst Immunol, Rikshosp, Oslo, Norway

[2] Haukeland Hosp, Norwegian Multiple Sclerosis Competence Ctr, Dept Neurol, N-5021 Bergen, Norway

[3] Akershus Univ Hosp, Dept Neurol, Lorenskog, Norway

[4] Univ Oslo, Fac Med, Oslo, Norway

来源：

VIRUSES-BASEL | 2012年 / 4卷 / 12期

关键词：

systemic lupus erythematosus; rheumatoid arthritis; multiple sclerosis; Epstein-Barr virus; autoimmunity; B-cells; T-cells; BLOOD MONONUCLEAR-CELLS; ALTERED IMMUNE-RESPONSE; CENTRAL-NERVOUS-SYSTEM; ALPHA-B-CRYSTALLIN; MEMBRANE-PROTEIN; CD8(+) T-CELLS; TRANSLATIONAL MINIREVIEW SERIES; ENDOGENOUS RETROVIRUS HERV-K18; BZLF-1-ENCODED ZEBRA PROTEIN; PERIPHERAL-BLOOD;

D O I：

10.3390/v4123701

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Epidemiological data suggest that Epstein-Barr virus (EBV) is associated with several autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis. However, it is not clear whether EBV plays a role in the pathogenesis of these diseases, and if so, by which mechanisms the virus may contribute. In this review, we discuss possible viral and immunological mechanisms that might explain associations between EBV and autoimmune diseases and whether these associations represent causes or effects of inflammation and autoimmunity.

引用

页码：3701 / 3730

页数：30

共 230 条

[1]

Serum and CSF measles antibody levels increase over time in patients with multiple sclerosis or clinically isolated syndrome [J].