Therapeutic Enzyme-Responsive Nanoparticles for Targeted Delivery and Accumulation in Tumors

被引：220

作者：

Callmann, Cassandra E. ^{[1
]}

Barback, Christopher V. ^{[2
]}

Thompson, Matthew P. ^{[1
]}

Hall, David J. ^{[2
]}

Mattrey, Robert F. ^{[2
]}

Gianneschi, Nathan C. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA

来源：

ADVANCED MATERIALS | 2015年 / 27卷 / 31期

关键词：

drug delivery; enzyme-responsive; nanomaterials; self-assembly; stimuli-responsive; OPENING METATHESIS POLYMERIZATION; CELL-PENETRATING PEPTIDES; OLEFIN METATHESIS; DRUG-DELIVERY; INTRATUMORAL CHEMOTHERAPY; ANTITUMOR-ACTIVITY; AMINOPEPTIDASE N; LUNG-CANCER; MOUSE MODEL; CATALYSTS;

D O I：

10.1002/adma.201501803

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An enzyme-responsive, paclitaxel-loaded nanoparticle is described and assessed in vivo in a human fibrosarcoma murine xenograft. This work represents a proof-of-concept study demonstrating the utility of enzyme-responsive nanoscale drug carriers capable of targeted accumulation and retention in tumor tissue in response to overexpressed endogenous enzymes. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4611 / 4615

页数：5

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