Elevation of serum IGF-1 rather than sex steroids precedes proliferative diabetic retinopathy in Mauriac's syndrome

被引：5

作者：

Chantelau, E

Seppel, T

Althaus, C

Schonau, E

机构：

[1] UNIV DUSSELDORF, DEPT ENDOCRINOL, D-40001 DUSSELDORF, GERMANY

[2] UNIV DUSSELDORF, DEPT OPHTHALMOL, D-40001 DUSSELDORF, GERMANY

[3] UNIV COLOGNE, DEPT PEDIAT, D-5000 COLOGNE 41, GERMANY

来源：

HORMONE RESEARCH | 1997年 / 48卷 / 03期

关键词：

diabetes mellitus; complications; metabolic control; retinopathy; glycosylated hemoglobin;

D O I：

10.1159/000185502

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report the case of a 21-year-old man with Mauriac's syndrome, in whom diabetic retinopathy progressed to the proliferative state despite slightly improved glycemic control and completely suppressed sex steroids (by a GnRH agonist). However, a gradual increase in serum IGF-1 from 162 to 482 ng/ml over 9 months clearly preceded retinal deterioration, which responded to panretinal laser coagulation. We conclude that substantial elevation of serum IGF-1 may be another risk factor for the progression of mild diabetic retinopathy to the proliferative state.

引用

页码：131 / 134

页数：4

共 23 条

[1]

ALDINGTON SJ, 1995, DIABETOLOGIA, V38, P437, DOI 10.1007/BF00410281

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