Kinesin: the tail unfolds

被引：19

作者：

Cross, R ^{[1
]}

Scholey, J

机构：

[1] Marie Curie Res Inst, Mol Motors Grp, Surrey RH8 0TL, England

[2] Univ Calif Davis, Sct Mol & Cellular Biol, Davis, CA 95616 USA

来源：

NATURE CELL BIOLOGY | 1999年 / 1卷 / 05期

关键词：

D O I：

10.1038/12947

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The cargo-binding tail of the motor protein kinesin acts as a regulator of kinesin-driven vesicle transport. In the absence of bound cargo, the kinesin tail interacts with the motor domains and inhibits their activity. Cargo binding blocks this interaction and relieves the inhibition.

引用

页码：E119 / E121

页数：3

共 18 条

[1]

AMOS LA, 1987, J CELL SCI, V87, P105

[2] Kinesin- and myosin-driven steps of vesicle recruitment for Ca2+-regulated exocytosis [J].

Bi, GQ ;

Morris, RL ;

Liao, GC ;

Alderton, JM ;

Scholey, JM ;

Steinhardt, RA .

JOURNAL OF CELL BIOLOGY, 1997, 138 (05) :999-1008

[3] Kinesin's tail domain is an inhibitory regulator of the motor domain [J].

Coy, DL ;

Hancock, WO ;

Wagenbach, M ;

Howard, J .

NATURE CELL BIOLOGY, 1999, 1 (05) :288-292

[4] The C-terminal region of the stalk domain of ubiquitous human kinesin heavy chain contains the binding site for kinesin light chain [J].

Diefenbach, RJ ;

Mackay, JP ;

Armati, PJ ;

Cunningham, AL .

BIOCHEMISTRY, 1998, 37 (47) :16663-16670

[5] Single-molecule analysis of kinesin motility reveals regulation by the cargo-binding tail domain [J].

Friedman, DS ;

Vale, RD .

NATURE CELL BIOLOGY, 1999, 1 (05) :293-297

[6] Kinesin light chains are essential for axonal transport in Drosophila [J].

Gindhart, JG ;

Desai, CJ ;

Beushausen, S ;

Zinn, K ;

Goldstein, LSB .

JOURNAL OF CELL BIOLOGY, 1998, 141 (02) :443-454

[7]

HACKNEY DD, 1992, J BIOL CHEM, V267, P8696

[8] SUBMOLECULAR DOMAINS OF BOVINE BRAIN KINESIN IDENTIFIED BY ELECTRON-MICROSCOPY AND MONOCLONAL-ANTIBODY DECORATION [J].

HIROKAWA, N ;

PFISTER, KK ;

YORIFUJI, H ;

WAGNER, MC ;

BRADY, ST ;

BLOOM, GS .

CELL, 1989, 56 (05) :867-878

[9] THE MOLECULAR-STRUCTURE OF ADRENAL-MEDULLA KINESIN [J].

HISANAGA, S ;

MUROFUSHI, H ;

OKUHARA, K ;

SATO, R ;

MASUDA, Y ;

SAKAI, H ;

HIROKAWA, N .

CELL MOTILITY AND THE CYTOSKELETON, 1989, 12 (04) :264-272

[10] PHOSPHORYLATION OF NEURONAL KINESIN HEAVY AND LIGHT-CHAINS INVIVO [J].

HOLLENBECK, PJ .

JOURNAL OF NEUROCHEMISTRY, 1993, 60 (06) :2265-2275

← 1 2 →