Non-lytic expulsion/exocytosis of Candida albicans from macrophages

被引：76

作者：

Bain, Judith M. ^{[1
]}

Lewis, Leanne E. ^{[1
]}

Okai, Blessing ^{[1
]}

Quinn, Janet ^{[2
]}

Gow, Neil A. R. ^{[3
]}

Erwig, Lars-Peter ^{[1
]}

机构：

[1] Univ Aberdeen, Sch Med & Dent, Aberdeen AB25 2ZD, Scotland

[2] Newcastle Univ, Fac Med Sci, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[3] Univ Aberdeen, Sch Med Sci, Aberdeen Fungal Grp, Aberdeen AB25 2ZD, Scotland

来源：

FUNGAL GENETICS AND BIOLOGY | 2012年 / 49卷 / 09期

基金：

英国惠康基金;

关键词：

Candida albicans; Macrophage; Phagocytosis; Innate immunology; Fungal infection; PHAGOCYTOSIS;

D O I：

10.1016/j.fgb.2012.01.008

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Candida albicans is an opportunistic pathogen and is recognised and phagocytosed by macrophages. Using live-cell imaging, non-lytic expulsion/exocytosis of C. albicans from macrophages is demonstrated for the first time. Following complete expulsion, both the phagocyte and pathogen remain intact and viable. Partial engulfment of hyphal C albicans without macrophage lysis is also demonstrated. These observations underpin the complexity of interactions between C. albicans and innate immune cells. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：677 / 678

页数：2

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