Therapeutic potential of type A (I) lantibiotics, a group of cationic peptide antibiotics

被引：65

作者：

Smith, Leif ^{[1
]}

Hillman, J. D. ^{[1
]}

机构：

[1] Oragenics Inc, Antimicrobial Div, Alachua, FL 32615 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2008年 / 11卷 / 05期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/j.mib.2008.09.008

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

Type A (I) lantibiotics are cationic antimicrobial peptides that have a potential usefulness in treating infectious diseases. They are known to have a potent and broad spectrum of activity, an insignificant cytotoxicity, and demonstrated efficacy in animal infection models, suggesting therapeutic potential. In this review, topics pertaining to their basic structure, mode of bactericidal activity, pharmacology, and methods of manufacture are described.

引用

页码：401 / 408

页数：8

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