Changes in subcortical structures in early- versus late-onset Alzheimer's disease

被引：46

作者：

Cho, Hanna ^{[1
]}

Seo, Sang Won ^{[1
]}

Kim, Jeong-Hun ^{[2
]}

Kim, Changsoo ^{[3
,4
]}

Ye, Byoung Seok ^{[1
]}

Kim, Geon Ha ^{[1
]}

Noh, Young ^{[1
]}

Kim, Hee Jin ^{[1
]}

Yoon, Cindy W. ^{[1
]}

Seong, Joon-Kyung ^{[5
]}

Kim, Chang-Hun ^{[6
]}

Kang, Sue J. ^{[1
]}

Chin, Juhee ^{[1
]}

Kim, Sung Tae ^{[7
]}

Lee, Kyung-Han ^{[8
]}

Na, Duk L. ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurol, Seoul 135710, South Korea

[2] Korea Univ, Dept Comp & Radio Commun Engn, Seoul, South Korea

[3] Yonsei Univ, Coll Med, Dept Prevent Med, Seoul, South Korea

[4] Yonsei Univ, Coll Med, Inst Environm Res, Seoul, South Korea

[5] Korea Univ, Dept Biomed Engn, Seoul, South Korea

[6] Korea Univ, Dept Brain & Cognit Engn, Seoul, South Korea

[7] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Radiol, Seoul 135710, South Korea

[8] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Nucl Med, Seoul 135710, South Korea

来源：

NEUROBIOLOGY OF AGING | 2013年 / 34卷 / 07期

关键词：

Alzheimer's Disease; Onset age; Early onset; Subcortical structure; Longitudinal study; Amygdala; Hippocampus; Thalamus; Putamen; Globus pallidus; Caudate nucleus; Basal ganglia; DEMENTIA; DIAGNOSIS; ATROPHY; AGE;

D O I：

10.1016/j.neurobiolaging.2013.01.001

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Patients with early-onset Alzheimer's disease (EOAD) are reported to be different from those with late-onset Alzheimer's disease (LOAD) in terms of neuropsychological and neuroimaging findings. In this study, we aimed to compare the longitudinal volume changes of 6 subcortical structures (the amygdala, hippocampus, thalamus, putamen, globus pallidus, and caudate nucleus) between patients with EOAD and LOAD for 3 years. We prospectively recruited 36 patients with probable Alzheimer's disease (14 EOAD, 22 LOAD) and 14 normal control subjects. We analyzed the volume of subcortical structures using an automatic surface-based method. At baseline, there were no differences in the volumes of subcortical structures between patients with EOAD and LOAD. However, over 3 years of longitudinal follow-up, patients with EOAD showed more rapid volumetric decline in the caudate, putamen, and thalamus than patients with LOAD, which is consistent with neuropsychological results. Our findings suggested that the cognitive reserve theory might be applicable to explain different decline rates of the volumes of the basal ganglia and thalamus according to onset age. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：1740 / 1747

页数：8

共 33 条

[1]

The cortical neuroanatomy of neuropsychological deficits in mild cognitive impairment and Alzheimer's disease: A surface-based morphometric analysis [J].