Activation of vocal fold healing with topical vitamin A in rabbits

被引：14

作者：

Akdogan, Ozgur ^{[1
]}

Selcuk, Adin ^{[1
]}

Ozcan, Ibrahim ^{[1
]}

Ozcan, Kuersat Murat ^{[1
]}

Giray, Seren Gulsen ^{[2
]}

Dere, Huseyin ^{[1
]}

Ozogul, Candan ^{[2
]}

机构：

[1] Ankara Numune Training & Res Hosp, ENT Clin 4, Ankara, Turkey

[2] Gazi Univ, Fac Med, Dept Histol & Embryol, Ankara, Turkey

来源：

ACTA OTO-LARYNGOLOGICA | 2009年 / 129卷 / 02期

关键词：

Rabbit; vocal fold; vitamin A; acute healing; HEPATOCYTE GROWTH-FACTOR; INJECTABLE COLLAGEN; INJECTION;

D O I：

10.1080/00016480802087219

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 [耳鼻咽喉科学];

摘要：

Conclusion. The results suggest that vitamin A can prevent scar formation in the vocal fold after surgery. Objectives. This study aimed to evaluate the effects of topically applied vitamin A on healing after vocal fold trauma. Materials and methods. Vocal folds of 20 adult rabbits were traumatized unilaterally. Ten of them were treated with topical application of vitamin A and the others served as controls. All animals were sacrificed after 10 days. Vocal folds were resected for analysis by light microscopy. Results. The untreated vocal folds showed extensive deposition of collagen and fibroblast on light microscopy and vocal folds treated with vitamin A showed less deposition. There was a significant difference between the two groups according to the percentage of collagen and fibroblasts in the lamina propria (p0.01).

引用

页码：220 / 224

页数：5

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