Genetic Variation in the Lymphotoxin-Alpha Pathway and the Risk of Ischemic Stroke in European Populations

被引：19

作者：

Freilinger, Tobias ^{[1
]}

Bevan, Steve ^{[2
]}

Ripke, Stephan ^{[3
]}

Gschwendtner, Andreas

Lichtner, Peter ^{[4
]}

Mueller-Myhsok, Bertram ^{[3
]}

Wichmann, H. -Erich ^{[5
,6
]}

Markus, Hugh S. ^{[2
]}

Meitinger, Thomas ^{[4
,7
]}

Dichgans, Martin

机构：

[1] Univ Munich, Klinikum Grosshadern, Neurolog Klin & Poliklin, Dept Neurol, D-81377 Munich, Germany

[2] Univ London, Ctr Clin Neurosci, London WC1E 7HU, England

[3] Max Planck Inst Psychiat, D-80804 Munich, Germany

[4] HelmholtzZentrum Munchen, Inst Human Genet, Munich, Germany

[5] HelmholtzZentrum Munchen, Inst Epidemiol, Munich, Germany

[6] Univ Munich, Chair Epidemiol, IBE, D-81377 Munich, Germany

[7] Tech Univ Munich, Inst Human Genet, D-80804 Munich, Germany

来源：

STROKE | 2009年 / 40卷 / 03期

关键词：

stroke; genetics; PSMA6; LTA; LGALS2; MYOCARDIAL-INFARCTION; CONFERS RISK; SUSCEPTIBILITY; DISEASE; SNPS;

D O I：

10.1161/STROKEAHA.107.510800

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-Several genes involved in the lymphotoxin-alpha cascade (LTA, LGALS2, and PSMA6) have been linked with the risk of myocardial infarction. Here, we present a comprehensive analysis of these genes in patients with ischemic stroke (IS). Methods-Twenty-three single nucleotide polymorphisms (SNPs) from LTA, LGALS2, and PSMA6 were genotyped in 601 German IS patients and 736 matched controls. SNPs and haplotypes were tested for association with overall IS, large vessel stroke, and cardioembolic stroke. Significant associations were replicated in an independent sample of 843 IS cases and 933 controls from the UK. Results-Only one SNP (rs1048990 in PSMA6) showed association with overall IS, but this was not replicated in the UK sample. Three SNPs showed significant associations with stroke subtypes (P<0.05), but none of these associations could be replicated in the UK population. Conclusions-Genetic variation in the lymphotoxin-alpha cascade (LTA, LGALS2, and PSMA6) is not a major risk factor for IS. (Stroke. 2009; 40: 970-972.)

引用

页码：970 / 972

页数：3

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