The ER-Golgi intermediate compartment (ERGIC): in search of its identity and function

被引:328
作者
Appenzeller-Herzog, Christian [1 ]
Hauri, Hans-Peter [1 ]
机构
[1] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland
关键词
ER-exit sites; ER-to-Golgi transport; ERGIC-53; protein sorting; COPI; COPII; tethering; fusion;
D O I
10.1242/jcs.03019
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Protein traffic moving from the endoplasmic reticulum ( ER) to the Golgi complex in mammalian cells passes through the tubulovesicular membrane clusters of the ERGolgi intermediate compartment ( ERGIC), the marker of which is the lectin ERGIC-53. The dynamic nature and functional role of the ERGIC have been debated for quite some time. In the most popular current view, the ERGIC clusters are mobile transport complexes that deliver secretory cargo from ER-exit sites to the Golgi. Recent live-cell imaging data revealing the formation of anterograde carriers from stationary ERGIC-53- positive membranes, however, suggest a stable compartment model in which ER-derived cargo is first shuttled from ER-exit sites to stationary ERGIC clusters in a COPII-dependent step and subsequently to the Golgi in a second vesicular transport step. This model can better accommodate previous morphological and functional data on ER-to- Golgi traffic. Such a stationary ERGIC would be a major site of anterograde and retrograde sorting that is controlled by coat proteins, Rab and Arf GTPases, as well as tethering complexes, SNAREs and cytoskeletal networks. The ERGIC also contributes to the concentration, folding, and quality control of newly synthesized proteins.
引用
收藏
页码:2173 / 2183
页数:11
相关论文
共 142 条
  • [1] Rab1 recruitment of p115 into a cis-SNARE complex: Programming budding COPII vesicles for fusion
    Allan, BB
    Moyer, BD
    Balch, WE
    [J]. SCIENCE, 2000, 289 (5478) : 444 - 448
  • [2] Alvarez C, 2003, MOL BIOL CELL, V14, P2116, DOI 10.1091/mbc.E02-09-0625
  • [3] The p115-interactive proteins GM130 and giantin participate in endoplasmic reticulum-Golgi traffic
    Alvarez, C
    Garcia-Mata, R
    Hauri, HP
    Sztul, E
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (04) : 2693 - 2700
  • [4] ER to Golgi transport: Requirement for p115 at a pre-Golgi VTC stage
    Alvarez, C
    Fujita, H
    Hubbard, A
    Sztul, E
    [J]. JOURNAL OF CELL BIOLOGY, 1999, 147 (06) : 1205 - 1221
  • [5] Modulation of intracellular transport by transported proteins: Insight from regulation of COPI-mediated transport
    Aoe, T
    Lee, AJ
    van Donselaar, E
    Peters, PJ
    Hsu, VW
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (04) : 1624 - 1629
  • [6] The lectin ERGIC-53 is a cargo transport receptor for glycoproteins
    Appenzeller, C
    Andersson, H
    Kappeler, F
    Hauri, HP
    [J]. NATURE CELL BIOLOGY, 1999, 1 (06) : 330 - 334
  • [7] pH-induced conversion of the transport lectin ERGIC-53 triggers glycoprotein release
    Appenzeller-Herzog, C
    Roche, AC
    Nufer, O
    Hauri, HP
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (13) : 12943 - 12950
  • [8] Carbohydrate- and conformation-dependent cargo capture for ER-exit
    Appenzeller-Herzog, C
    Nyfeler, B
    Burkhard, P
    Santamaria, I
    Lopez-Otin, C
    Hauri, HP
    [J]. MOLECULAR BIOLOGY OF THE CELL, 2005, 16 (03) : 1258 - 1267
  • [9] Cargo can modulate COPII vesicle formation from the endoplasmic reticulum
    Aridor, M
    Bannykh, SI
    Rowe, T
    Balch, WE
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (07) : 4389 - 4399
  • [10] SEQUENTIAL COUPLING BETWEEN COPII AND COPI VESICLE COATS IN ENDOPLASMIC-RETICULUM TO GOLGI TRANSPORT
    ARIDOR, M
    BANNYKH, SI
    ROWE, T
    BALCH, WE
    [J]. JOURNAL OF CELL BIOLOGY, 1995, 131 (04) : 875 - 893