Tumor-specific mutations in p53: The acid test

被引：22

作者：

Hainaut, P ^{[1
]}

机构：

[1] Int Agcy Res Canc, Mol Carcinogenesis Grp, F-69372 Lyon, France

来源：

NATURE MEDICINE | 2002年 / 8卷 / 01期

关键词：

D O I：

10.1038/nm0102-21

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tumor-specific, 'signature' mutations of p53 have been identified in several cancers. The molecular basis of these tissue-specific selections has been poorly understood. A recent report sheds light on this issue by identifying the molecular basis of one such signature mutation found in adrenal cortical carcinomas.

引用

页码：21 / 23

页数：3

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