Grand mal convulsion and plasma concentrations after intravascular injection of ropivacaine for axillary brachial plexus blockade

被引：46

作者：

Müller, M ^{[1
]}

Litz, RJ ^{[1
]}

Hübler, M ^{[1
]}

Albrecht, DM ^{[1
]}

机构：

[1] Carl Gustav Carus Univ Hosp, Dept Anaesthesiol & Intens Care Med, D-01307 Dresden, Germany

来源：

BRITISH JOURNAL OF ANAESTHESIA | 2001年 / 87卷 / 05期

关键词：

complications; convulsions; anaesthetics local; ropivacaine;

D O I：

10.1093/bja/87.5.784

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

We report a patient to whom ropivacaine 1.1 mg kg(-1) was administered for brachial plexus blockade and who developed grand mal convulsions because of inadvertent i.v. injection. No symptoms of cardiovascular toxicity occurred. Venous blood samples were taken 15, 45, 75 and 155 min after the injection. The measured total plasma concentrations of ropivacaine were 3.3, 1.6, 1.2 and 1.0 mg litre(-1) respectively. Initial plasma concentration after the end of the injection period was estimated at 5.75 mg litre(-1) using a two-compartment pharmacokinetic model.

引用

页码：784 / 787

页数：4

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