Low Cerebral Oxygen Consumption and Blood Flow in Patients With Cirrhosis and an Acute Episode of Hepatic Encephalopathy

被引：85

作者：

Iversen, Peter ^{[1
,2
]}

Sorensen, Michael ^{[1
,2
]}

Bak, Lasse Kristoffer ^{[3
]}

Waagepetersen, Helle Sonderby ^{[3
]}

Vafaee, Manouchehr Seyedi ^{[2
,4
]}

Borghammer, Per ^{[2
,4
]}

Mouridsen, Kim ^{[4
]}

Jensen, Svend Borup ^{[2
]}

Vilstrup, Hendrik ^{[1
]}

Schousboe, Arne ^{[3
]}

Ott, Peter ^{[1
]}

Gjedde, Albert ^{[2
,4
]}

Keiding, Susanne ^{[1
,2
]}

机构：

[1] Aarhus Univ Hosp, Dept Med 5, DK-8000 Aarhus, Denmark

[2] Aarhus Univ Hosp, PET Ctr, DK-8000 Aarhus, Denmark

[3] Univ Copenhagen, Dept Pharmacol & Pharmacotherapy, Fac Pharmaceut Sci, Copenhagen, Denmark

[4] Aarhus Univ Hosp, CFIN, DK-8000 Aarhus, Denmark

来源：

GASTROENTEROLOGY | 2009年 / 136卷 / 03期

基金：

英国医学研究理事会;

关键词：

ACUTE LIVER-FAILURE; REGIONAL DIFFERENCES; GLUCOSE-METABOLISM; AMMONIA METABOLISM; BRAIN; PET; DISEASE; PATHOPHYSIOLOGY;

D O I：

10.1053/j.gastro.2008.10.057

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background & Aims: It is unclear whether patients with hepatic encephalopathy (HE) have disturbed brain oxygen metabolism and blood flow. Methods: We measured cerebral oxygen metabolism rate (CMRO2) by using O-15-oxygen positron emission tomography (PET); and cerebral blood flow (CBF) by using O-15-water PET in 6 patients with liver cirrhosis and an acute episode of overt HE, 6 cirrhotic patients without HE, and 7 healthy subjects. Results: Neither whole-brain CMRO2 nor CBF differed significantly between cirrhotic patients without HE and healthy subjects, but were both significantly reduced in cirrhotic patients with HE (P < .01). CMRO2 was 0.96 +/- 0.07 mu mol oxygen/mL brain tissue/min (mean +/- SEM) in cirrhotic patients with HE, 1.34 +/- 0.08 in cirrhotic patients without HE, and 1.35 +/- 0.05 in healthy subjects; and CBF was 0.29 +/- 0.01 mL blood/mL brain tissue/min in patients with HE, 0.47 +/- 0.02 in patients without HE, and 0.49 +/- 0.03 in healthy subjects. CMRO2 and CBF were correlated, and both variables correlated negatively with arterial ammonia concentration. Analysis of regional values, using individual magnetic resonance co-registrations, showed that the reductions in CMRO2 and CBF in patients with HE were essentially generalized throughout the brain. Conclusions: The observations imply that reduced cerebral oxygen consumption and blood flow in cirrhotic patients with an acute episode of overt HE are associated with HE and not cirrhosis as such, and that the primary event in the pathogenesis of HE could be inhibition of cerebral energy metabolism by increased blood ammonia.

引用

页码：863 / 871

页数：9

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[1] Pathophysiology of hepatic encephalopathy: A new look at GABA from the molecular standpoint [J].