Ion trap tandem mass spectrometry study of dexamethasone transformation products on light activated TiO2 surface

被引:51
作者
Calza, P [1 ]
Pelizzetti, E [1 ]
Brussino, M [1 ]
Baiocchi, C [1 ]
机构
[1] Univ Turin, Dipartimento Chim Analit, I-10125 Turin, Italy
关键词
D O I
10.1016/S1044-0305(01)00319-1
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The photocatalytic transformation of dexamethasone and the formation of its intermediate compounds have been studied using titanium dioxide as a photocatalyst. The degradation of dexamethasone occurs easily through the formation of several hydroxy derivatives whose characterization has been made by HPLC/MS/MS. Even if both oxidative and reductive processes can be operating, only oxidative products have been identified in air saturated aqueous suspensions. A pattern of reaction pathways accounting for the observed intermediates is proposed. The obtained experimental evidence may be rationalized postulating the existence of a double initial mechanism. A single oxidation step resulting from the attack by one (OH)-O-. radical leading to the formation of five hydroxy-derivatives and a concomitant attack involving two (OH)-O-. radicals leading to the hydroxylation of the quinoid moiety of the molecule. (C) 2001 American Society for Mass Spectrometry.
引用
收藏
页码:1286 / 1295
页数:10
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