Recent and forgotten aspects of visceral pain

Progress in the field of visceral pain research has been particularly rapid in recent years. Some aspects of the symptom that had previously been neglected for some time have now received a great deal of attention in both clinical and experimental studies. This regards, in particular, phenomena of hyperalgesia: (a) of visceral structures, because of local inflammatory/sensitizing processes (visceral hyperalgesia); (b) of areas of referred pain from viscera (referred somatic hyperalgesia from visceral); and (c) of a visceral structure, because of an algogenic process of another visceral domain (viscero-visceral hyperalgesia). Clinical studies in patients have led to characterisation of subjective and objective symptoms of these phenomena. A number of studies in human volunteers (employing experimental procedures to stimulate and measure pain reactivity in both visceral structures and somatic areas of referral) have further increased the knowledge about modalities of generation of the various forms of hyperalgesia. Animal experiments have improved understanding of pathophysiological mechanisms, mostly those underlying the referred hyperalgesia, with a number of findings supporting the notion of central changes at the basis of the phenomenon. An important aspect of laboratory experiments in recent years has been the setting up of animal models of visceral pain conditions closely mimicking a number of clinical pain states in patients. As a result, the outcome of experimental studies (electrophysiological, pharmacological, etc.) appears more directly applicable to the interpretation of the clinical reality. Finally, in the context of laboratory studies, a novel trend of investigation is represented by genetic experiments, particularly those employing 'knock-out' mice. These experiments, by generating animals lacking specific genes responsible for the production of various receptors implicated in pain transmission, have further contributed to the understanding of the generation of visceral pain symptoms. Although studies in this field are in their early stage, they seem particularly promising for a better understanding of the pathophysiology of visceral pain, and thus the establishment of more satisfying therapies in the future.