Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI

被引：1105

作者：

Moore, Kevin W. ^{[1
]}

Vieira, Paulo ^{[1
]}

Fiorentino, David F. ^{[1
]}

Trounstine, Mary L. ^{[1
]}

Khan, Tariq A. ^{[1
]}

Mosmann, Timothy R. ^{[1
]}

机构：

[1] DNAX Res Inst Molec & Cellular Biol Inc, Dept Immunol, Palo Alto, CA 94304 USA

来源：

JOURNAL OF IMMUNOLOGY | 2012年 / 189卷 / 05期

关键词：

T-CELL CLONE; FC-RECEPTOR; LEISHMANIA-TROPICA; INTERFERON-GAMMA; MESSENGER-RNA; DNA-SEQUENCE; TH2; CLONES; IFN-GAMMA; B-CELLS; ANTIGEN;

D O I：

10.1126/science.2161559

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Complementary DNA clones encoding mouse cytokines synthesis inhibitory factor (CSIF; interleukin-10), which inhibits cytokine synthesis T(H)l helper T cells, were isolated and expressed. The predicted protein sequence shows extensive homology with an uncharacterized open reading frame, BCRFI, in the Epstein-Barr virus genome, suggesting the possibility that this herpes virus exploits the biological activity of a captured cytokine gene to enhance its survival in the host.

引用

页码：1230 / 1234

页数：5

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