Melanocytes in development, regeneration, and cancer

被引：104

作者：

White, Richard Mark ^{[1
,2
,3
]}

Zon, Leonard I. ^{[1
,2
,3
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[2] Childrens Hosp, Stem Cell Program, Div Hematol Oncol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

CELL STEM CELL | 2008年 / 3卷 / 03期

关键词：

D O I：

10.1016/j.stem.2008.08.005

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The genes required for stem cell specification and lineage restriction during embryogenesis also play fundamental roles in adult tissue regeneration and cancer. This "development-regeneration-cancer" axis is exemplified by the vertebrate pigmentation system. Melanocytes exhibit almost unlimited self-renewal capacity during regenerative processes such as mammalian hair recoloration and zebrafish fin regeneration. Melanoma utilizes many regulatory signals and pathways required during ontogeny and regeneration. A discussion of these interconnections highlights how studies of stem cell function in embryonic and regenerative contexts can yield insights into melanoma biology.

引用

收藏

页码：242 / 252

页数：11

相关论文

共 95 条

[1] L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition [J].

Antonescu, Cristina R. ;

Busam, Klaus J. ;

Francone, Todd D. ;

Wong, Grace C. ;

Guo, Tianhua ;

Agaram, Narasimhan P. ;

Besmer, Peter ;

Jungbluth, Achim ;

Gimbel, Mark ;

Chen, Chin-Tung ;

Veach, Darren ;

Clarkson, Bayard D. ;

Paty, Philip B. ;

Weiser, Martin R. .

INTERNATIONAL JOURNAL OF CANCER, 2007, 121 (02) :257-264

[2] Involvement of microphthalmia-associated transcription factor (MITF) in expression of human melanocortin-1 receptor (MC1R) [J].

Aoki, H ;

Moro, O .

LIFE SCIENCES, 2002, 71 (18) :2171-2179

[3] Endothelin B receptor blockade inhibits dynamics of cell interactions and communications in melanoma cell progression [J].

Bagnato, A ;

Rosanò, L ;

Spinella, F ;

Di Castro, V ;

Tecce, R ;

Natali, PG .

CANCER RESEARCH, 2004, 64 (04) :1436-1443

[4]

Baker CVH, 1997, DEVELOPMENT, V124, P3077

[5] Activation of Notch1 signaling is required for β-catenin-mediated human primary melanoma progression [J].

Balint, K ;

Xiao, M ;

Pinnix, CC ;

Soma, A ;

Veres, I ;

Juhasz, I ;

Brown, EJ ;

Capobianco, AJ ;

Herlyn, M ;

Liu, ZJ .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (11) :3166-3176

[6] Dual inactivation of RB and p53 pathways in RAS-induced melanomas [J].

Bardeesy, N ;

Bastian, BC ;

Hezel, A ;

Pinkel, D ;

DePinho, RA ;

Chin, L .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (06) :2144-2153

[7] INTERACTION OF ENDOTHELIN-3 WITH ENDOTHELIN-B RECEPTOR IS ESSENTIAL FOR DEVELOPMENT OF EPIDERMAL MELANOCYTES AND ENTERIC NEURONS [J].

BAYNASH, AG ;

HOSODA, K ;

GIAID, A ;

RICHARDSON, JA ;

EMOTO, N ;

HAMMER, RE ;

YANAGISAWA, M .

CELL, 1994, 79 (07) :1277-1285

[8] Molecular classification of cutaneous malignant melanoma by gene expression profiling [J].

Bittner, M ;

Meitzer, P ;

Chen, Y ;

Jiang, Y ;

Seftor, E ;

Hendrix, M ;

Radmacher, M ;

Simon, R ;

Yakhini, Z ;

Ben-Dor, A ;

Sampas, N ;

Dougherty, E ;

Wang, E ;

Marincola, F ;

Gooden, C ;

Lueders, J ;

Glatfelter, A ;

Pollock, P ;

Carpten, J ;

Gillanders, E ;

Leja, D ;

Dietrich, K ;

Beaudry, C ;

Berens, M ;

Alberts, D ;

Sondak, V ;

Hayward, N ;

Trent, J .

NATURE, 2000, 406 (6795) :536-540

[9] CELL LINEAGE ANALYSIS REVEALS MULTIPOTENCY OF SOME AVIAN NEURAL CREST CELLS [J].

BRONNERFRASER, M ;

FRASER, SE .

NATURE, 1988, 335 (6186) :161-164

[10] The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression [J].

Cano, A ;

Pérez-Moreno, MA ;

Rodrigo, I ;

Locascio, A ;

Blanco, MJ ;

del Barrio, MG ;

Portillo, F ;

Nieto, MA .

NATURE CELL BIOLOGY, 2000, 2 (02) :76-83

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