The effect of reperfusion on neuroprotection using an inhibitor of poly(ADP-ribose) polymerase

被引：36

作者：

Takahashi, K ^{[1
]}

Greenberg, JH ^{[1
]}

Greenberg, H ^{[1
]}

机构：

[1] Univ Penn, Cerebrovasc Res Ctr, Philadelphia, PA 19104 USA

来源：

NEUROREPORT | 1999年 / 10卷 / 10期

关键词：

3-aminobenzamide; ischemia-reperfusion injury; laser Doppler flowmetry; middle cerebral artery occlusion; neuroprotection; Poly(ADP-ribose) polymerase; rats;

D O I：

10.1097/00001756-199907130-00005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE activation of poly(ADP-ribose) polymerase (PARP) by free radical-damaged DNA plays a pivotal role in mediating ischemia-reperfusion injury. The purpose of the present study was to examine the neuroprotective effects of a PARP inhibitor, 3-aminobenzamide (3-ABA), which was administered either prior to or following reperfusion, to determine the importance of PARP inhibition prior to reperfusion. 3-ABA was injected i.p. either 15 min before or 15 min following reperfusion in a transient focal ischemia model in the rat. Treatment prior to the reperfusion led to a significant decrease in the volume of damaged tissue at 24 h (118.7 +/- 18.8 mm(3), mean +/- s.d., p < 0.01), compared with the control (176.1 +/- 22.8 mm(3)). However, treatment after the reperfusion failed to produce a reduction in the damaged volume (171.9 +/- 27.6 mm(3)). These findings suggest that PARP activation sufficient to produce cellular damage occurs immediately after the reperfusion following cerebral ischemia. NeuroReport 10:2017-2022 (C) 1999 Lippincott Williams & Wilkins.

引用

页码：2017 / 2022

页数：6

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