Homocysteine trials - Clear outcomes for complex reasons

被引：234

作者：

Loscalzo, J

机构：

[1] Brigham & Womens Hosp, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2006年 / 354卷 / 15期

关键词：

D O I：

10.1056/NEJMe068060

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：1629 / 1632

页数：4

共 19 条

[1] Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia or hypercholesterolemia [J].

Böger, RH ;

Bode-Böger, SM ;

Sydow, K ;

Heistad, DD ;

Lentz, SR .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (06) :1557-1564

[2] Homocysteine lowering and cardiovascular events after acute myocardial infarction [J].

Bonaa, KH ;

Njolstad, I ;

Ueland, PM ;

Schirmer, H ;

Tverdal, A ;

Steigen, T ;

Wang, H ;

Nordrehaug, JE ;

Arnesen, E ;

Rasmussen, K .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (15) :1578-1588

[3] Power shortage: Clinical trials testing the "homocysteine hypothesis" against a background of folic acid-fortified cereal grain flour [J].

Bostom, AG ;

Selhub, J ;

Jacques, PF ;

Rosenberg, IH .

ANNALS OF INTERNAL MEDICINE, 2001, 135 (02) :133-139

[4] Homocysteine and risk of ischemic heart disease and stroke -: A meta-analysis [J].

Clarke, R ;

Collins, R ;

Lewington, S ;

Donald, A ;

Alfthan, G ;

Tuomilehto, J ;

Arnesen, E ;

Bonaa, K ;

Blacher, J ;

Boers, GHJ ;

Bostom, A ;

Bots, ML ;

Grobee, DE ;

Brattström, L ;

Breteler, MMB ;

Hofman, A ;

Chambers, JC ;

Kooner, JS ;

Coull, BM ;

Evans, RW ;

Kuller, LH ;

Evers, S ;

Folsom, AR ;

Freyburger, G ;

Parrot, F ;

Genst, J ;

Dalery, K ;

Graham, IM ;

Daly, L ;

Hoogeveen, EK ;

Kostense, PJ ;

Stehouwer, CDA ;

Hopknis, PN ;

Jacques, P ;

Selhub, J ;

Luft, FC ;

Jungers, P ;

Lindgren, A ;

Lolin, YI ;

Loehrer, F ;

Fowler, B ;

Mansoor, MA ;

Malinow, MR ;

Ducimetiere, P ;

Nygard, O ;

Refsum, H ;

Vollset, SE ;

Ueland, PM ;

Omenn, GS ;

Beresford, SAA .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (16) :2015-2022

[5] Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice [J].

Devlin, AM ;

Arning, E ;

Bottiglieri, T ;

Faraci, FM ;

Rozen, R ;

Lentz, SR .

BLOOD, 2004, 103 (07) :2624-2629

[6] Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering [J].

Doshi, SN ;

McDowell, IFW ;

Moat, SJ ;

Payne, N ;

Durrant, HJ ;

Lewis, MJ ;

Goodfellow, J .

CIRCULATION, 2002, 105 (01) :22-26

[7] Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia [J].

Eberhardt, RT ;

Forgione, MA ;

Cap, A ;

Leopold, JA ;

Rudd, MA ;

Trolliet, M ;

Heydrick, S ;

Stark, R ;

Klings, ES ;

Moldovan, NI ;

Yaghoubi, M ;

Goldschmidt-Clermont, PJ ;

Farber, HW ;

Cohen, R ;

Loscalzo, J .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (04) :483-491

[8] Folate therapy and in-stent restenosis after coronary stenting [J].

Lange, H ;

Suryapranata, H ;

De Luca, G ;

Börner, C ;

Dille, J ;

Kallmayer, K ;

Pasalary, MN ;

Scherer, E ;

Dambrink, JHE .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (26) :2673-2681

[9]

Lonn E, 2006, NEW ENGL J MED, V354, P1567, DOI 10.1056/NEJMoa060900

[10] Adverse effects of supplemental L-arginine in atherosclerosis - Consequences of methylation stress in a complex catabolism? [J].

Loscalzo, J .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (01) :3-5

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