A BAC transgenic mouse model to analyze the function of astroglial SPARCL1 (SC1) in the central nervous system

被引：15

作者：

Weimer, Jill M. ^{[1
]}

Stanco, Amelia ^{[1
]}

Cheng, Jr-Gang ^{[1
]}

Vargo, Ana C. ^{[1
]}

Voora, Santhi ^{[1
]}

Anton, E. S. ^{[1
,2
]}

机构：

[1] Univ N Carolina, Sch Med, UNC Neurosci Ctr, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Sch Med, Dept Cell & Mol Physiol, Chapel Hill, NC 27599 USA

来源：

GLIA | 2008年 / 56卷 / 09期

关键词：

cerebral cortex; astroglia; SPARCL1; Sc1; fatty acid binding protein 7; fabp7;

D O I：

10.1002/glia.20666

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Extracellular matrix associated Sparc-like 1 (SC1/SPARCL1) can influence the function of astroglial cells in the developing and mature central nervous system (CNS). To examine SC1's significance in the CNS, we generated a BAC transgenic mouse model in which Sc1 is expressed in radial glia and their astrocyte derivatives using the astroglial-specific Blbp (Brain-lipid binding protein; [Feng et al., (1994) Neuron 12:895-908]) regulatory elements. Characterization of these Blbf-Sc1 transgenic mice show elevated Sc1 transcript and protein in an astroglial selective pattern throughout the CNS. This model provides a novel in vivo system for evaluating the role of SC1 in brain development and function, in general, and for understanding SC1's significance in the fate and function of astroglial cells, in particular. (C) 2008 Wiley-Liss, Inc.

引用

页码：935 / 941

页数：7

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