A mechanistic overview of translation initiation in eukaryotes

被引：304

作者：

Aitken, Colin Echeverria ^{[1
]}

Lorsch, Jon R. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Biophys & Biophys Chem, Baltimore, MD 21205 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2012年 / 19卷 / 06期

关键词：

START CODON SELECTION; 40S RIBOSOMAL-SUBUNIT; RNA RECOGNITION MOTIF; GTP EXCHANGE FACTORS; BOX PROTEIN EIF4A; MESSENGER-RNA; IN-VIVO; PREINITIATION COMPLEX; SACCHAROMYCES-CEREVISIAE; POLY(A)-BINDING PROTEIN;

D O I：

10.1038/nsmb.2303

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Translation initiation in eukaryotes is a complex and highly regulated process requiring the action of at least 12 protein factors. The pathway is distinguished by the formation of a pre-initiation complex that recruits the 5' end of the mRNA and scans along it to locate the start codon. During the past decade, a combination of genetics, biochemistry and structural studies has begun to illuminate key molecular events in this critical phase of gene expression. Here, we outline our current understanding of eukaryotic translation initiation and discuss important outstanding challenges.

引用

页码：568 / 576

页数：9

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