Controlled Release of Encapsulated Cargo from a DNA Icosahedron using a Chemical Trigger

被引：106

作者：

Banerjee, Anusuya ^{[1
]}

Bhatia, Dhiraj ^{[1
]}

Saminathan, Anand ^{[1
]}

Chakraborty, Saikat ^{[1
]}

Kar, Shaunak ^{[1
]}

Krishnan, Yamuna ^{[1
]}

机构：

[1] Natl Ctr Biol Sci, UAS GKVK, Bangalore, Karnataka, India

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 27期

基金：

英国惠康基金;

关键词：

aptamers; cargo release; DNA icosahedron; drug delivery; encapsulation; DI-GMP;

D O I：

10.1002/anie.201302759

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

DNA Trojan horse: A DNA icosahedron (black, see scheme) held together with aptamers (red) was used to encapsulate molecular cargo such as fluorescent dextran (green). In the presence of a molecular trigger (gray hexagons), the aptamers fold back leading to opening of the icosahedron and simultaneous release of the encapsulated cargo. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6854 / 6857

页数：4

共 23 条

[1] Assembling materials with DNA as the guide [J].

Aldaye, Faisal A. ;

Palmer, Alison L. ;

Sleiman, Hanadi F. .

SCIENCE, 2008, 321 (5897) :1795-1799

[2]

[Anonymous], 2011, ANGEW CHEM INT ED, V50, P3124

[3]

[Anonymous], 2009, ANGEW CHEM INT ED, V48, P4134

[4]

[Anonymous], 2010, ANGEW CHEM INT ED, V49, P6216

[5]

Bhatia D.Bhatia, 2009, ANGEW CHEM, V121, P4198, DOI DOI 10.1002/ANGE.200806000

[6] GENE DELIVERY Designer DNA give RNAi more spine [J].

Bhatia, Dhiraj ;

Chakraborty, Saikat ;

Krishnan, Yamuna .

NATURE NANOTECHNOLOGY, 2012, 7 (06) :344-346

[7] A synthetic icosahedral DNA-based host-cargo complex for functional in vivo imaging [J].

Bhatia, Dhiraj ;

Surana, Sunaina ;

Chakraborty, Saikat ;

Koushika, Sandhya P. ;

Krishnan, Yamuna .

NATURE COMMUNICATIONS, 2011, 2

[8] Single-molecule tools elucidate H2A.Z nucleosome composition [J].

Chen, Jiji ;

Miller, Andrew ;

Kirchmaier, Ann L. ;

Irudayaraj, Joseph M. K. .

JOURNAL OF CELL SCIENCE, 2012, 125 (12) :2954-2964

[9]

Duchardt-Ferner E., 2010, ANGEW CHEM, V122, P6352

[10] Homo-FRET microscopy in living cells to measure monomer-dimer transition of GFP-tagged proteins [J].

Gautier, I ;

Tramier, M ;

Durieux, C ;

Coppey, J ;

Pansu, RB ;

Nicolas, JC ;

Kemnitz, K ;

Coppey-Moisan, M .

BIOPHYSICAL JOURNAL, 2001, 80 (06) :3000-3008

← 1 2 3 →