Mitochondria in malaria and related parasites: ancient, diverse and streamlined

被引：40

作者：

Mather, Michael W. ^{[1
]}

Vaidya, Akhil B. ^{[1
]}

机构：

[1] Drexel Univ, Coll Med, Dept Microbiol & Immunol, Ctr Mol Parasitol, Philadelphia, PA 19129 USA

来源：

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 2008年 / 40卷 / 05期

关键词：

Mitochondrial evolution; Mitochondrion-derived organelle; Human parasite; Apicomplexa; Plasmodium; Toxoplasma; Cryptosporidium; Mitochondrially-targeted drug;

D O I：

10.1007/s10863-008-9176-4

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Parasitic organisms have emerged from nearly every corner of the eukaryotic kingdom and hence display tremendous diversity of form and function. This diversity extends to their mitochondria and mitochondrion-derived organelles. While the principles of the chemiosmotic theory apply to all these pathogens, the differences from their hosts provide opportunities for therapeutic development. In this review we discuss examples of mitochondrial systems from a deep-branching phylum, Apicomplexa. Many important human pathogens, such as malaria parasites, belong to this phylum. Unique features of their mitochondria are validated targets for drugs that are selectively toxic to the parasites.

引用

页码：425 / 433

页数：9

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